Ciliary Tissue Transplantation in the Rabbit Eye: Does the Localization of the Graft Affect Survival?

Basit Öğe Kaydı
dc.authoridYAYLACIOGLU TUNCAY, FULYA/0000-0002-2088-3416
dc.contributor.authorYazici, Hulya
dc.contributor.authorGurelik, Gokhan
dc.contributor.authorTuncay, Fulya Yaylacioglu
dc.contributor.authorGocun, Pinar Uyar
dc.date.accessioned2025-10-24T18:09:29Z
dc.date.available2025-10-24T18:09:29Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: To examine whether ciliary body transplantation is applicable, the graft is viable and the localization of the graft material affects graft survival. Methods: Fifteen female New Zealand white rabbits were used. Three of them were used as donors, and a ciliary body graft was prepared from their enucleated eyes. There are two groups in the study according to the localization of the ciliary body graft in the anterior chamber. The graft was placed on the iris surface close to the pupil margin in group 1 and adjacent to the anterior chamber angle in group 2. Immunosuppressive treatment with cyclosporine A was given to the rabbits of both groups. The rabbits were sacrificed 1 month after ciliary transplantation, and their eyes were enucleated. After fixation, the graft and the surrounding tissue were examined by a pathologist macroscopically and microscopically with hematoxylin and eosin staining. Results: One month after the transplantation, the treated eyes, remained inflammation free, and the transplants seemed to be viable with evident vascularization and without hemorrhage and necrotic tissue. When we compared groups 1 and 2, there were no statistically significant differences in the histopathological findings between the groups. The grafts were found to be similar with normal ciliary tissue in regard to necrosis, hemorrhage and fibrosis, and there were no statistically significant differences in inflammatory cell density and in the epithelial cell morphology between the normal ciliary tissue and the grafts. Conclusion: Transplantation of allograft ciliary tissue either onto the surface of the iris or the anterior chamber angle under immunosuppression could be an effective treatment for chronic ocular hypotony. (C) 2016 S. Karger AG, Basel
dc.description.sponsorshipScientific Research Fund of TUBITAK [01-2011/96]
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of TUBITAK (grant No. 01-2011/96).
dc.identifier.doi10.1159/000446320
dc.identifier.endpage76
dc.identifier.issn0030-3747
dc.identifier.issn1423-0259
dc.identifier.issue1
dc.identifier.pmid27388749
dc.identifier.scopus2-s2.0-84978505297
dc.identifier.scopusqualityQ2
dc.identifier.startpage70
dc.identifier.urihttps://doi.org/10.1159/000446320
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3669
dc.identifier.volume57
dc.identifier.wosWOS:000390083500008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofOphthalmic Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCiliary tissue transplantation; Rabbit; Graft localization
dc.titleCiliary Tissue Transplantation in the Rabbit Eye: Does the Localization of the Graft Affect Survival?
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu