Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients

Basit Öğe Kaydı
dc.authoridKaygusuz, Ikbal/0000-0002-5635-505X;
dc.contributor.authorEser, Ayla
dc.contributor.authorGumus, Ilknur Inegol
dc.contributor.authorErdamar, Husamettin
dc.contributor.authorKaygusuz, Ikbal
dc.contributor.authorYildirim, Melahat
dc.contributor.authorUsluogullari, Betul
dc.contributor.authorErdolu, Muzeyyen Duran
dc.date.accessioned2025-10-24T18:09:11Z
dc.date.available2025-10-24T18:09:11Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable fibrinolysis inhibitor (carboxypeptidase B2) between women with a history of recurrent miscarriage and those with no recurrent miscarriage history. Materials and methods: A case-controlled, prospective study design was adopted to compare women with a history of two or more first-trimester miscarriages (n = 42) with those with no history of recurrent miscarriage (n = 36). Participants were recruited from the Department of Obstetrics and Gynecology of Turgut Ozal University Hospital. Platelet-activating factor and thrombin-activatable fibrinolysis inhibitor levels in serum samples were measured by an enzyme-linked immunosorbent assay. Results: Platelet-activating factor levels were significantly (p = 0.018) higher in the recurrent miscarriage group. There was no difference in levels of thrombin-activatable fibrinolysis inhibitor expression between the groups. Conclusion: Platelet-activating factor is significantly higher in serum of patients with a history of recurrent miscarriage than in those without such a history, with potential implications for placental function and fetal growth, which could be relevant to miscarriage recurrence. Larger studies are indicated to further examine these findings. Copyright (C) 2016, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC.
dc.description.sponsorshipFatih University [1337]
dc.description.sponsorshipFatih University financially supported this research (grant no: 1337).
dc.identifier.doi10.1016/j.tjog.2015.06.013
dc.identifier.endpage63
dc.identifier.issn1028-4559
dc.identifier.issue1
dc.identifier.pmid26927250
dc.identifier.scopus2-s2.0-84959128747
dc.identifier.scopusqualityQ2
dc.identifier.startpage60
dc.identifier.urihttps://doi.org/10.1016/j.tjog.2015.06.013
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3497
dc.identifier.volume55
dc.identifier.wosWOS:000373413600013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Taiwan
dc.relation.ispartofTaiwanese Journal Of Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectabortion; habitual; carboxypeptidase B2; platelet activating factor; pregnancy
dc.titleLevels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu