Association Between N-Terminal Pro-Brain Natriuretic Peptide Levels and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome

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dc.authoridSensoy, Baris/0000-0003-0066-9946|Acikgoz, Sadik Kadri/0000-0001-8241-4642|Yarlioglues, Mikail/0000-0001-8905-9807|, Mustafa Cetin/0000-0001-7542-6602;
dc.contributor.authorKurtul, Alparslan
dc.contributor.authorDuran, Mustafa
dc.contributor.authorYarlioglues, Mikail
dc.contributor.authorMurat, Sani Namik
dc.contributor.authorDemircelik, Muhammed Bora
dc.contributor.authorErgun, Gokhan
dc.contributor.authorAcikgoz, Sadik Kadri
dc.date.accessioned2025-10-24T18:08:46Z
dc.date.available2025-10-24T18:08:46Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Contrast-induced nephropathy (CIN) is associated with significantly increased morbidity and mortality after percutaneous coronary intervention (PCI). Patients with acute coronary syndrome (ACS) are at higher risk for CIN. N-terminal pro-brain natriuretic peptide (NT-proBNP) is closely linked to the prognosis as a strong predictor of both short-and long-term mortality in patients with ACS. Hypothesis: We hypothesized that NT-proBNP levels on admission can predict the development of CIN after PCI for ACS. Methods: A total of 436 patients (age 62.27 +/- 13.01 years; 64.2% male) with ACS undergoing PCI enrolled in this study. Admission NT-proBNP levels were measured before PCI. Serum creatinine values were measured before and within 72 hours after the administration of contrast agents. Patients were divided into 2 groups: CIN group and no-CIN group. CIN was defined as an increase in serum creatinine level of >= 0.5 mg/dL or >= 25% above baseline within 72 hours after contrast administration. Results: CIN developed in 63 patients (14.4%). Baseline NT-proBNP levels were significantly higher in patients who developed CIN compared to those who did not develop CIN (median 774 pg/mL, interquartile range 177.4-2184 vs median 5159 pg/mL, interquartile range 2282-9677, respectively; P < 0.001). Multivariate analysis found that NT-proBNP (odds ratio [OR]: 3.448, 95% confidence interval [CI]: 1.394-8.474, P = 0.007) and baseline creatinine (OR: 6.052, 95% CI: 1.860-19.686, P = 0.003) were independent predictors of CIN. Conclusions: Admission NT-proBNP level is an independent predictor of the development of CIN after PCI in ACS.
dc.identifier.doi10.1002/clc.22291
dc.identifier.endpage492
dc.identifier.issn0160-9289
dc.identifier.issn1932-8737
dc.identifier.issue8
dc.identifier.pmid24805995
dc.identifier.scopus2-s2.0-84906314821
dc.identifier.scopusqualityQ2
dc.identifier.startpage485
dc.identifier.urihttps://doi.org/10.1002/clc.22291
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3281
dc.identifier.volume37
dc.identifier.wosWOS:000340528400006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAcute Kidney Injury; Acute Myocardial-Infarction; Chronic Heart-Failure; Risk Stratification; Prediction; Disease; Cells; Mortality; Cardiology; Creatinine
dc.titleAssociation Between N-Terminal Pro-Brain Natriuretic Peptide Levels and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
dc.title.alternativeAssociation between N-terminal pro-brain natriuretic peptide levels and contrast-induced nephropathy in patients undergoing percutaneous coronary intervention for acute coronary syndrome
dc.typeArticle

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