Synthesis a group of 5(6)-substituted benzimidazole Zn(II) and Co(II) complexes and investigation their cytotoxic and antimicrobial activities

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dc.authorid0000-0002-2806-4781en_US
dc.contributor.authorYılmaz, Ülkü
dc.contributor.authorApohan, Elif
dc.contributor.authorKüçükbay, Hasan
dc.contributor.authorYılmaz, Özgür
dc.contributor.authorTatlıcı, Eray
dc.contributor.authorYeşilada, Özfer
dc.date.accessioned2022-03-22T13:08:27Z
dc.date.available2022-03-22T13:08:27Z
dc.date.issued2022en_US
dc.departmentMTÖ Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Mühendislik Temel Bilimleri Bölümüen_US
dc.description.abstractA series of 5(6)-substituted benzimidazole ligand-zinc(II) and cobalt(II) complexes were synthesized and characterized by 1H, 13C NMR, IR, CHN analysis techniques. In vitro, anticancer and antimicrobial activities of ligand and complexes were evaluated. The cytotoxic activities of compounds were investigated against the human lung adenocarcinoma (A549) cell lines and healthy human lung bronchial epithelium (BEAS2B) cells. Compounds 1, 6, and 8 were observed to exhibit higher cytotoxic activity than the others at the 72nd hour. Also, the compounds showed varying degrees of antimicrobial activity against the microorganisms used. Compounds 1, 5, and 8 were most effective against standard strains Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 29213. As for the antifungal activity, compounds 1, 5, 6, and 8 showed high antifungal activity against the yeast type fungi Candida albicans ATCC 90028 and Candida tropicalis.en_US
dc.identifier.citationYılmaz, Ü., Apohan, E., Küçükbay, H., Yılmaz, Ö., Tatlıcı, E., & Yeşilada, Ö. (2022). Synthesis a group of 5 (6)‐substitutedbenzimidazole Zn (II) and Co (II) complexes and investigation their cytotoxic and antimicrobial activities. Journal of Heterocyclic Chemistry.en_US
dc.identifier.doi10.1002/jhet.4463
dc.identifier.scopus2-s2.0-85124735058en_US
dc.identifier.urihttps://doi.org/10.1002/jhet.4463
dc.identifier.urihttps://hdl.handle.net/20.500.12899/779
dc.identifier.wosWOS:000757226100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYılmaz, Ülkü
dc.language.isoenen_US
dc.relation.ispartofJ Heterocyclic Chem.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSynthesis a group of 5(6)-substituted benzimidazole Zn(II) and Co(II) complexes and investigation their cytotoxic and antimicrobial activitiesen_US
dc.typeArticleen_US

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