Assessment of early atherosclerotic findings in patients with nasal polyposis

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dc.authoridSomdas, Mehmet/0000-0003-2978-0971
dc.contributor.authorSagit, Mustafa
dc.contributor.authorSarli, Bahadir
dc.contributor.authorGuler, Sabri
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorKurtul, Serkan
dc.contributor.authorKorkmaz, Ferhat
dc.date.accessioned2025-10-24T18:08:58Z
dc.date.available2025-10-24T18:08:58Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: To investigate early markers of atherosclerosis in patients with nasal polyposis (NP) through measurements of carotid artery intima-media thickness (CIMT), flow-mediated vasodilatation (FMD) of the brachial artery and serum paraoxonase-1 (PON-1) activity. Methods: Forty-five patients with NP were included in the study group and 45 healthy individuals in the control group. The diagnosis of patients with NP was predicated on anterior rhinoscopy, endoscopic nasal examination and coronal paranasal sinus computed tomography (CT). Measurements of CIMT and FMD of the brachial artery were performed by high-resolution ultrasonography. Serum PON-1 activity was evaluated by measuring the rate of paraoxon hydrolysis. Results: Mean CIMT values were found to be increased in the NP group compared to the control group. However, mean FMD % values and serum PON-1 activity were significantly lower in the NP group compared to the control group. Moreover; the endoscopic polyps' scores and paranasal sinus CT scores were positively correlated with CIMT and negatively correlated with FMD % values and PON-1 activity. Disease duration also was positively correlated with CIMT and negatively correlated with FMD % values. Conclusion: Impaired FMD, increased CIMT and decreased serum PUN-1 activity may be considered to be risk factors for accelerated atherosclerosis in patients with NP who may have subclinical atherosclerosis and be at risk for cardiovascular events in the future. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.anl.2013.07.013
dc.identifier.endpage184
dc.identifier.issn0385-8146
dc.identifier.issn1879-1476
dc.identifier.issue2
dc.identifier.pmid24148525
dc.identifier.scopus2-s2.0-84893982792
dc.identifier.scopusqualityQ2
dc.identifier.startpage179
dc.identifier.urihttps://doi.org/10.1016/j.anl.2013.07.013
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3380
dc.identifier.volume41
dc.identifier.wosWOS:000333321800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofAuris Nasus Larynx
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectNasal polyposis; Carotid artery intima-media thickness; Flow-mediated vasodilatation; Paraoxonase; Atherosclerosis
dc.titleAssessment of early atherosclerotic findings in patients with nasal polyposis
dc.typeArticle

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