The Prognostic Value of High Pretreatment Plasma D-Dimer Levels in Non-Metastatic Breast Cancer Patients with Absence of Venous Thromboembolism

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dc.contributor.authorKacan, Turgut
dc.contributor.authorYucel, Birsen
dc.contributor.authorBahar, Seher
dc.contributor.authorCelasun, Gurol
dc.contributor.authorSeker, Mehmet M.
dc.contributor.authorBabacan, Nalan
dc.contributor.authorBahceci, Aykut
dc.date.accessioned2025-10-24T18:10:02Z
dc.date.available2025-10-24T18:10:02Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractSystemic activation of coagulation and fibrinolysis is frequently observed in cancer patients without thrombosis. Recent studies have showed the association between D-Dimer (DD) and metastatic spread and prognosis of cancer. We aimed to investigate the prognostic value of DD in patients with non metestatic breast cancer (nMBC) and evaluated the DD levels and other variables for overall survival (OS) using univariate and multivariate analyses in 448 patients. The median follow-up time was 50 months (3-151 months). There was only significant relationship between DD and distant metastases (p=0.052). Performance status (PS) (p<0.001 and < 0.001), stage (p<0.001 and < 0.001), CEA (p<0.001 and < 0.001), CA 15-3 (p<0.001 and < 0.001) and DD (p<0.001 and 0.034) were determined as prognostic factors for OS in univariate analysis. In multivariate analysis, PS (ECOG 0 vs ECOG 1, p=0.022; ECOG 0 vs ECOG >= 2, (p<0.001), stage (stage I vs stage II, p=0.566; stage I vs stage III, p=0.033), the CA 15-3 (p=0.048) and DD levels (p=0.015) were determined as independent prognostic factors for OS. In conclusion, pretreatment high DD level is an important prognostic factor in patients with non metastatic breast cancer and high DD levels were associated with poor outcome.
dc.identifier.doi10.4999/uhod.161266
dc.identifier.endpage144
dc.identifier.issn1306-133X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84995776207
dc.identifier.scopusqualityQ4
dc.identifier.startpage136
dc.identifier.trdizinid203449
dc.identifier.urihttps://doi.org/10.4999/uhod.161266
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/203449
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3952
dc.identifier.volume26
dc.identifier.wosWOS:000388276400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherAkad Doktorlar Yayinevi
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectD-Dimer; Non-metastatic breast cancer; Prognosis
dc.titleThe Prognostic Value of High Pretreatment Plasma D-Dimer Levels in Non-Metastatic Breast Cancer Patients with Absence of Venous Thromboembolism
dc.title.alternativeTedavi öncesi yüksek d-dimer düzeylerinin venöz tromboembolisi olmayan non-metastatik meme kanserli hastalardaki prognostik önemi
dc.typeArticle

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