Role of ?-glutamyl transferase levels in prediction of high cardiovascular risk among patients with non-alcoholic fatty liver disease

Basit Öğe Kaydı
dc.authoridYALCIN, Kadir Serkan/0000-0002-8028-1070;
dc.contributor.authorKasapoglu, Benan
dc.contributor.authorTurkay, Cansel
dc.contributor.authorYalcin, Kadir Serkan
dc.contributor.authorCarlioglu, Ayse
dc.contributor.authorKoktener, Asli
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground & objectives: Non-alcoholic fatty liver disease (NAFLD) is an important cause of elevated liver functions. There is evidence showing an association between NAFLD and subclinical atherosclerosis independent of traditional risk factors. We undertook this retrospective study to determine the association of Framingham cardiovascular risk scoring system with liver function tests and inflammatory markers and to find the role of liver function tests in determination of CVD risk among non-obese and nondiabetic subjects with non-alcoholic fatty liver disease. Methods: A total of 2058 patients were included in the study. Framingham cardiovascular risk scoring was done of all patients according to the age, gender, systolic blood pressure, serum total cholesterol and HDL cholesterol levels, smoking and antihypertensive medication history. Liver function test, lipid profile, insulin, uric acid, ferritin levels, etc. were determined. Results: According to the ultrasonography findings, patients were grouped as without any fatty infiltration of the liver (control group) (n= 982), mild (n= 473), moderate (n= 363) and severe fatty liver disease (n= 240) groups. In severe fatty liver disease group, the mean Framingham cardiovascular risk score was significantly higher than that of other groups. There was a positive correlation between GGT, uric acid and ferritin levels with Framingham cardiovascular score. In multivariate analysis, high GGT levels were positively associated with high-risk disease presence (OR: 3.02, 95% CI: 2.62-3.42) compared to low GGT levels independent of the age and sex. Interpretation & conclusions: Cardiovascular disease risk increases with the presence and stage of fatty liver disease. Our findings showed a positive correlation between elevated GGT levels and Framingham cardiovascular risk scoring system among non-diabetic, non-obese adults which could be important in clinical practice. Though in normal limits, elevated GGT levels among patients with fatty liver disease should be regarded as a sign of increased cardiovascular disease risk. Larger studies are warranted to elucidate the role of GGT in prediction of cardiovascular risk.
dc.identifier.doi10.4103/0971-5916.178585
dc.identifier.endpage36
dc.identifier.issn0971-5916
dc.identifier.pmid26997011
dc.identifier.scopus2-s2.0-84960965212
dc.identifier.scopusqualityQ1
dc.identifier.startpage30
dc.identifier.urihttps://doi.org/10.4103/0971-5916.178585
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3892
dc.identifier.volume143
dc.identifier.wosWOS:000373279900008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal Of Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectBMI; cardiovascular disease risk score; Framingham; gamma glutamyl transferase; non-alcoholic fatty liver disease; non-obese
dc.titleRole of ?-glutamyl transferase levels in prediction of high cardiovascular risk among patients with non-alcoholic fatty liver disease
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu