Decreased brain-derived neurotrophic factor levels may predict early perioperative neurocognitive disorder in patients undergoing coronary artery bypass surgery: A prospective observational pilot study

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dc.authoridCicekcioglu, Ferit/0000-0002-4809-0100|KACMAZ, OSMAN/0000-0002-1219-7758|KILIC, Mahmut/0000-0002-8921-1597|Miniksar, Okkes Hakan/0000-0001-5645-7729
dc.contributor.authorMiniksar, Okkes Hakan
dc.contributor.authorCicekcioglu, Ferit
dc.contributor.authorKilic, Mahmut
dc.contributor.authorHonca, Mehtap
dc.contributor.authorMiniksar, Dilsad Yildiz
dc.contributor.authorGocmen, Ayse Yesim
dc.contributor.authorKacmaz, Osman
dc.date.accessioned2025-10-24T18:09:04Z
dc.date.available2025-10-24T18:09:04Z
dc.date.issued2021
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractStudy objective: To determine the prognostic value of the change in intraoperative BDNF (Brain-derived neurotrophic factor) levels during cardiac surgery with cardiopulmonary bypass (CPB) on early perioperative neurocognitive disorder (PND). Design: Prospective observational pilot study. Setting: The study was performed in the Medical Faculty Hospital, from January 2020 to August 2020. Patients: 45 adult patients undergoing elective coronary artery bypass surgery (CABG) with CPB. Interventions: None. Measurements: Cognitive function was evaluated 1 day before and 4 days after the surgery. Serum BDNF levels were measured at four time points (T1: after induction; T2: with aortic cross-clamp; T3: without aortic crossclamp; T4: 4 days after surgery) by enzyme-linked immunosorbent assay. Main results: The incidence of PND was 37.8% four days after surgery. Serum BDNF (T2 and T4) levels were significantly lower in PND group compared to non- PND group (p = 0.003 and p = 0.016, respectively). Moreover, lactate, rSO2 (regional cerebral oxygen saturation), aortic cross-clamp time, CPB duration, and the amount of blood transfusion differed between the groups. Logistic regression analysis identified serum BDNF-T2, age, cross-clamp time, and rSO2-T2 as independent risk factors for PND. Based on the ROC analysis, the area under curve (AUC) of BDNF-T2 concentration for prediction of PND was 0.759 with sensitivity of 71.4% and specificity of 64.7% (p < 0.01). Conclusion: Intraoperative BDNF serum levels may be a useful biomarker in predicting PND in patients undergoing CABG surgery. More comprehensive studies is needed in order to confirm the effect of decreasing intraoperative BDNF serum levels on the development of PND. Trial registration number: NCT04250935 www.clinicaltrials.gov.
dc.identifier.doi10.1016/j.jclinane.2021.110235
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.pmid33774438
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2021.110235
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3455
dc.identifier.volume71
dc.identifier.wosWOS:000661281300017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofJournal Of Clinical Anesthesia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCoronary artery bypass grafting; Postoperative cognitive dysfunction; Brain-derived neurotrophic factor; Predictor
dc.titleDecreased brain-derived neurotrophic factor levels may predict early perioperative neurocognitive disorder in patients undergoing coronary artery bypass surgery: A prospective observational pilot study
dc.typeArticle

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