Emerging roles of ADAMTS metalloproteinases in regenerative medicine and restorative biology

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dc.contributor.authorArmutcu, Ferah
dc.contributor.authorDemircan, Kadir
dc.date.accessioned2025-10-24T18:09:48Z
dc.date.available2025-10-24T18:09:48Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteinases degrade proteoglycans and thereby have the potential to alter tissue architecture and regulate cellular function. Recent studies about the roles of these enzymes have produced new perspectives for the molecular mechanisms behind regenerative biology with clinical potential to generate therapeutic targets to resolve tissue injury. ADAMTS enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as inflammation and fibrosis. Increasing evidence indicates that they may be of key significance in the physiological and pathological central nervous system. In this review, we summarize what is currently known about the roles of ADAMTS proteins in tissue repair and regeneration as well as in the pathogenesis of other important biological processes and diseases including arthritis, atherosclerosis, and cancer.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK); TUBITAK by SBAG Grant [113S428]; TUBITAK SBAG Grant [3501]
dc.description.sponsorshipThe authors acknowledge the support of the Scientific and Technological Research Council of Turkey (TUBITAK). F Armutcu and K Demircan were funded by TUBITAK by SBAG Grant 113S428 and K Demircan was funded by TUBITAK SBAG Grant 3501.
dc.identifier.doi10.3906/biy-1505-32
dc.identifier.endpage315
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85045847098
dc.identifier.scopusqualityQ1
dc.identifier.startpage308
dc.identifier.urihttps://doi.org/10.3906/biy-1505-32
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3837
dc.identifier.volume40
dc.identifier.wosWOS:000370808100005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectRegenerative biology; ADAMTS; extracellular matrix; nervous system; chronic disease
dc.titleEmerging roles of ADAMTS metalloproteinases in regenerative medicine and restorative biology
dc.typeReview Article

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