Malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during diferent trimesters of pregnancy and in the cord blood of newborns
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: To determine whether levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathioneperoxidase (GPx), and catalase (CAT) change during the 3 trimesters of pregnancy, and to compare the third trimester of pregnancywith newborn cord blood in respect to the levels of MDA, NO, and antioxidant enzymes.Materials and methods: Maternal blood samples were collected at 9 13, 22 26, and 36 40 weeks of gestation. Cord blood was collectedat the time of delivery.Results: NO levels and GPx activity were higher in the second and third trimesters than in the frst trimester. MDA level was lower in thethird trimester and SOD and CAT activities were lower in the second and third trimesters than the frst trimester. In cord blood, MDAand NO levels were lower while CAT and GPx activities were higher than in the third trimester of pregnancy.Conclusion: Tese results suggest that the balance of free radical and antioxidant production during pregnancy ensures healthy fetusgrowth and development.
Açıklama
Anahtar Kelimeler
Biyokimya ve Moleküler Biyoloji
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
45
Sayı
2
