The coexistence of renal cell carcinoma and diffuse large B-cell lymphoma with hypercalcemic crisis as the initial presentation

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dc.contributor.authorYilmaz, Hakki
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorBilgiç, Mukadder Ayşe
dc.contributor.authorBavbek, Nüket
dc.contributor.authorAkçay, Ali T.
dc.date.accessioned2025-10-24T18:06:45Z
dc.date.available2025-10-24T18:06:45Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntroduction. Severe hypercalcemia can be life threatening. The causes of hypercalcemia can be divided into seven categories: hyperparathyroidism, vitamin D-related causes, malignancy, medications, other endocrine disorders, genetic disorders, and miscellaneous causes. Evaluation of a patient with hypercalcemia should include a careful history and physical examination focusing on clinical manifestations of hypercalcemia, risk factors for malignancy, causative medications, and a family history of hypercalcemia-associated conditions (e.g. kidney stones). Hypercalcemia was clasified as serum levels of calcium: 1) mild hypercalcemia (calcium < 12 mg/dl), 2) moderate hypercalcemia (calcium between 12 and 14 mg/dl), and 3) severe hypercalcemia (calcium > 14 mg/dl). We should keep in mind that severe hypercalcemia was originated from two or more causes. This is the first report in the literature; renal cell carcinoma (RCC) and diffuse large B-cell lymphoma (DLBCL) presented severe paraneoplastic hypercalcemia. Case presentation. We report a case of a 63-year-old Turkish man with RCC and DLBCL who showed severe hypercalcemia (calcium=15.01 mg/dl) accompanied by elevation of serum parathyroid hormone-related protein (PTH-rP) as the initial presentation. While hypercalcemia is one of the complications of various types of cancerous diseases, it has not been reported still as the first presentation of the coexistence of RCC and DLBCL. After radical nephrectomy, the patient underwent six courses of chemotherapy consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone and achieved a complete remission that lasts 2 years. Conlusion. This case report describes a patient with two different malignancies (RCC and DLBCL) with the unusual presentation of hypercalcemia. We review the differential diagnosis and treatment of malignant hypercalcemia. We suggest that coexistence of DLBCL with RCC, although rare, should be considered as a possible causative in hypercalcemia of unknown underlying disease. © 2015 Elsevier B.V., All rights reserved.
dc.identifier.doi10.4149/endo_2014_03_113
dc.identifier.endpage119
dc.identifier.issn1336-0329
dc.identifier.issn1210-0668
dc.identifier.issue3
dc.identifier.pmid25110209
dc.identifier.scopus2-s2.0-84928629494
dc.identifier.scopusqualityQ3
dc.identifier.startpage113
dc.identifier.urihttps://doi.rog/10.4149/endo_2014_03_113
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3189
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInstitute of Experimental Endocrinology ueenregu@kramare.savba.sk
dc.relation.ispartofEndocrine Regulations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectDiffuse large B-cell lymphoma
dc.subjectParaneoplastic syndrome
dc.subjectRenal cell carcinoma
dc.subjectSevere hypercalcemia
dc.titleThe coexistence of renal cell carcinoma and diffuse large B-cell lymphoma with hypercalcemic crisis as the initial presentation
dc.typeArticle

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