Comparison of the efficacies of polycaprolactone filler and lidocaine-added filler on neocollagenesis in a rat model

Basit Öğe Kaydı
dc.authorid0000-0002-6578-3371en_US
dc.contributor.authorSezer,S., Saraç,G., Gül,M., Zayman,E.,Kapıcıoğlu,Y.
dc.date.accessioned2022-03-11T07:47:27Z
dc.date.available2022-03-11T07:47:27Z
dc.date.issued11 Aralık 2021en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Polycaprolactone (PCL) is a semi–permanent filler stimulating neocollagenesis. Lidocaine is frequently used to reduce the pain and, however, may have negative effects on collagen. It was aimed to compare the histological changes on rat skin and efficacies of PCL filler and lidocaine addition. Objective: In this study, results of PCL and PCL+Lidocaine application on rat skin were compared using hematoxylin–eosin (H&E) staining, Masson's trichrome (MT) staining, and electron microscope (EM). Methods: A total of 30 adult female rats were divided into three groups: the control group, the PCL group, and the PCL+Lidocaine group. The tissue samples taken at months 2 and 4 were examined using H&E, MT, and EM. Results: At month 2, dermis thickness, fibroblast count, and collagen fiber diameter increased similarly in the PCL and PCL+Lidocaine groups. Collagen fiber diameter was significantly higher in the PCL group than in the PCL+Lidocaine (p:0.016) and control groups (p:0.009). At month 4, no significant difference was detected between the PCL and PCL+Lidocaine groups in terms of fibroblast count, collagen fiber count, and collagen fiber diameter; dermis thickness was lower in the PCL+Lidocaine group at month 4 (p < 0.46). Dermis thickness, fibroblast count, collagen fiber count, and collagen fiber diameter were found to be significantly lower than in the PCL and PCL+Lidocaine groups. Conclusions: Our study showed that lidocaine addition to PCL filler does not affect the efficacy of the filler and PCL filler stimulates neocollagenesisen_US
dc.identifier.citationSezer, S., Sarac, G., Gul, M., Zayman, E., & Kapicioglu, Y. (2021). Comparison of the efficacies of polycaprolactone filler and lidocaine‐added filler on neocollagenesis in a rat model. Journal of cosmetic dermatology.en_US
dc.identifier.doi10.1111/jocd.14664
dc.identifier.endpage7en_US
dc.identifier.pmid34894046
dc.identifier.scopus2-s2.0-85120918108en_US
dc.identifier.startpage1en_US
dc.identifier.uridoi: 10.1111/jocd.14664
dc.identifier.urihttps://hdl.handle.net/20.500.12899/601
dc.identifier.wosWOS:000729097700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZayman, Emrah
dc.language.isoenen_US
dc.publisherwileyen_US
dc.relation.ispartofJ Cosmet Dermatol.en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdermal fillersen_US
dc.subjectlidocaineen_US
dc.subjectneocollagenesisen_US
dc.subjectpolycaprolactoneen_US
dc.titleComparison of the efficacies of polycaprolactone filler and lidocaine-added filler on neocollagenesis in a rat modelen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
zayman,e.2021.pdf
Boyut:
1.25 MB
Biçim:
Adobe Portable Document Format
Açıklama:
makale dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu