Increased serum interleukin-33 levels in patients with Graves' disease

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dc.contributor.authorÇelik, Hüseyin Tuğrul
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorBurnik, S. F.
dc.contributor.authorSezer, Sevilay
dc.contributor.authorSerdar, Muhittin A.
dc.contributor.authorErcan, Müjgan
dc.contributor.authorUğuz, Nihal
dc.date.accessioned2025-10-24T18:06:45Z
dc.date.available2025-10-24T18:06:45Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractobjective. Interleukin-33 (IL-33), a 30 kDa cytokine, is a member of IL-1 family. It is considered to be an autoimmune biomarker associated with T helper 2 (T 2) response. ?-interferon is also produced by T helper 1 (T 1) cells to induce cellular responses. ?-interferon is a 143-amino acid residue glycoprotein with several biological functions including potent anti-viral activity, stimulation of macrophage activity, modulation of Major Histocompatibilty Complex class I/class II expression, and regulation of a diversity of specific immune responses. Te aim of this study was to investigate the serum levels of IL-33 and ?-interferon in different thyroid disorders. Methods. Twenty patients with Graves' disease, 21 patients with Hashimoto hypothyroidism, 21 euthyroid Hashimoto patients, and 27 control subjects were recruited to this study. Blood samples were drawn and IL-33 and ?-interferon tests were analyzed from 89 participants. Serum IL-33 and ?-interferon analyses were performed by enzyme-linked immunosorbent assay. results. Tere was no statistically significant difference between groups for serum ?-interferon levels. Serum IL-33 concentrations were significantly higher in Graves' disease group compared to the other groups (p<0.000) There was a positive correlation between serum IL-33 and free triiodothyronine (fT3) and thyroxine (fT4). Also, negative correlation between serum IL-33 and thyroid-stimulating hormone (TSH) was statistically significant (p<0.000). Conclusions. Te correlation of serum IL-33 with thyroid hormone levels may be a useful indicator for Graves' disease. These findings may help to make evident the pathophysiologic processes of the autoimmune thyroid diseases and improve therapeutic methods. © 2013 Elsevier B.V., All rights reserved.; MEDLINE® is the source for the MeSH terms of this document.
dc.identifier.doi10.4149/endo_2013_02_57
dc.identifier.endpage64
dc.identifier.issn1336-0329
dc.identifier.issn1210-0668
dc.identifier.issue2
dc.identifier.pmid23641786
dc.identifier.scopus2-s2.0-84878390002
dc.identifier.scopusqualityQ3
dc.identifier.startpage57
dc.identifier.urihttps://doi.rog/10.4149/endo_2013_02_57
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3186
dc.identifier.volume47
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofEndocrine Regulations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectCytokines
dc.subjectHashimoto thyroiditis
dc.subjectHyperthyroiditis
dc.subjectInterleukin
dc.subjectThyroid disorders
dc.titleIncreased serum interleukin-33 levels in patients with Graves' disease
dc.typeArticle

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