Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey

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dc.authorid0000-0002-4609-1580en_US
dc.contributor.authorSavas Ozturk
dc.contributor.authorKenan Turgutalp
dc.contributor.authorMustafa Arici
dc.contributor.authorAli Riza Odabas
dc.contributor.authorMehmet Riza Altiparmak
dc.contributor.authorZeki Aydin
dc.contributor.authorEgemen Cebeci
dc.contributor.authorTaner Basturk
dc.contributor.authorZeki Soypacaci
dc.contributor.authorGarip Sahin
dc.contributor.authorTuba Elif Ozler
dc.contributor.authorEkrem Kara
dc.contributor.authorHamad Dheir
dc.contributor.authorNecmi Eren
dc.contributor.authorGultekin Suleymanlar
dc.contributor.authorMahmud Islam
dc.contributor.authorMelike Betul Ogutmen
dc.contributor.authorErkan Sengul
dc.contributor.authorYavuz Ayar
dc.contributor.authorMurside Esra Dolarslan
dc.contributor.authorSerkan Bakirdogen
dc.contributor.authorSeda Safak
dc.contributor.authorOzkan Gungor
dc.contributor.authorIdris Sahin
dc.contributor.authorIlay Berke Mentese
dc.contributor.authorOzgur Merhametsiz
dc.contributor.authorEbru Gok Oguz
dc.contributor.authorDilek Gibyeli Genek
dc.contributor.authorNadir Alpay
dc.contributor.authorNimet Aktas
dc.contributor.authorMurat Duranay
dc.contributor.authorSelma Alagoz
dc.contributor.authorHulya Colak
dc.contributor.authorZelal Adibelli
dc.contributor.authorIrem Pembegul
dc.contributor.authorEnder Hur
dc.contributor.authorAlper Azak
dc.contributor.authorDilek Guven Taymez
dc.contributor.authorErhan Tatar
dc.contributor.authorRumeyza Kazancioglu
dc.contributor.authorAysegul Oruc
dc.contributor.authorEnver Yuksel
dc.contributor.authorEngin Onan
dc.contributor.authorKultigin Turkmen
dc.contributor.authorNuri Baris Hasbal
dc.contributor.authorAli Gurel
dc.contributor.authorBerna Yelken
dc.contributor.authorTuncay Sahutoglu
dc.contributor.authorMahmut Gok
dc.contributor.authorNurhan Seyahi
dc.contributor.authorMustafa Sevinc
dc.contributor.authorSultan Ozkurt
dc.contributor.authorSavas Sipahi
dc.contributor.authorSibel Gokcay Bek
dc.contributor.authorFeyza Bora
dc.contributor.authorBulent Demirelli
dc.contributor.authorOzgur Akin Oto
dc.contributor.authorOrcun Altunoren
dc.contributor.authorSerhan Zubeyde Tuglular
dc.contributor.authorMehmet Emin Demir
dc.contributor.authorMehmet Deniz Ayli
dc.contributor.authorBulent Huddam
dc.contributor.authorMehmet Tanrisev
dc.contributor.authorIlter Bozaci
dc.contributor.authorMeltem Gursu
dc.contributor.authorBetul Bakar
dc.contributor.authorBulent Tokgoz
dc.contributor.authorHalil Zeki Tonbul
dc.contributor.authorAlaattin Yildiz
dc.contributor.authorSiren Sezer
dc.contributor.authorKenan Ates
dc.date.accessioned2022-12-19T12:41:59Z
dc.date.available2022-12-19T12:41:59Z
dc.date.issued2020en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Chronic kidney disease (CKD) and immunosuppression, such as in renal transplantation (RT), stand as one of the established potential risk factors for severe coronavirus disease 2019 (COVID-19). Case morbidity and mortality rates for any type of infection have always been much higher in CKD, haemodialysis (HD) and RT patients than in the general population. A large study comparing COVID-19 outcome in moderate to advanced CKD (Stages 3–5), HD and RT patients with a control group of patients is still lacking. Methods We conducted a multicentre, retrospective, observational study, involving hospitalized adult patients with COVID-19 from 47 centres in Turkey. Patients with CKD Stages 3–5, chronic HD and RT were compared with patients who had COVID-19 but no kidney disease. Demographics, comorbidities, medications, laboratory tests, COVID-19 treatments and outcome [in-hospital mortality and combined in-hospital outcome mortality or admission to the intensive care unit (ICU)] were compared. Results A total of 1210 patients were included [median age, 61 (quartile 1–quartile 3 48–71) years, female 551 (45.5%)] composed of four groups: control (n = 450), HD (n = 390), RT (n = 81) and CKD (n = 289). The ICU admission rate was 266/1210 (22.0%). A total of 172/1210 (14.2%) patients died. The ICU admission and in-hospital mortality rates in the CKD group [114/289 (39.4%); 95% confidence interval (CI) 33.9–45.2; and 82/289 (28.4%); 95% CI 23.9–34.5)] were significantly higher than the other groups: HD = 99/390 (25.4%; 95% CI 21.3–29.9; P?<?0.001) and 63/390 (16.2%; 95% CI 13.0–20.4; P?<?0.001); RT = 17/81 (21.0%; 95% CI 13.2–30.8; P = 0.002) and 9/81 (11.1%; 95% CI 5.7–19.5; P = 0.001); and control = 36/450 (8.0%; 95% CI 5.8–10.8; P?<?0.001) and 18/450 (4%; 95% CI 2.5–6.2; P?<?0.001). Adjusted mortality and adjusted combined outcomes in CKD group and HD groups were significantly higher than the control group [hazard ratio (HR) (95% CI) CKD: 2.88 (1.52–5.44); P = 0.001; 2.44 (1.35–4.40); P = 0.003; HD: 2.32 (1.21–4.46); P = 0.011; 2.25 (1.23–4.12); P = 0.008), respectively], but these were not significantly different in the RT from in the control group [HR (95% CI) 1.89 (0.76–4.72); P = 0.169; 1.87 (0.81–4.28); P = 0.138, respectively]. Conclusions Hospitalized COVID-19 patients with CKDs, including Stages 3–5 CKD, HD and RT, have significantly higher mortality than patients without kidney disease. Stages 3–5 CKD patients have an in-hospital mortality rate as much as HD patients, which may be in part because of similar age and comorbidity burden. We were unable to assess if RT patients were or were not at increased risk for in-hospital mortality because of the relatively small sample size of the RT patients in this study.en_US
dc.identifier.doi10.1093/ndt/gfaa271
dc.identifier.endpage2095en_US
dc.identifier.issue12en_US
dc.identifier.pmid33275763
dc.identifier.scopus2-s2.0-85097310948en_US
dc.identifier.startpage2083en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12899/1200
dc.identifier.volume35en_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPembegul, Irem
dc.language.isoenen_US
dc.publisherPembegul, Iremen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjecthaemodialysisen_US
dc.subjectkidney diseaseen_US
dc.subjectmortalityen_US
dc.subjectrenal transplantationen_US
dc.titleMortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkeyen_US
dc.typeArticleen_US

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