One more health benefit of blood donation: Reduces acute-phase reactants, oxidants and increases antioxidant capacity

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dc.contributor.authorYünce, Muharrem
dc.contributor.authorErdamar, Hüsamettin
dc.contributor.authorBayram, Nezihe Asli
dc.contributor.authorGök, Sumeyye
dc.date.accessioned2025-10-24T18:06:42Z
dc.date.available2025-10-24T18:06:42Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOne of the most important problems in finding blood donors is the inadequacy of volunteer number. To overcome this problem, one of the solutions we suggest is innovating new health benefits of blood donation. The aim of the present study is to investigate the effects of blood donation on oxidative status markers and acute-phase reactants. A total of 96 healthy volunteers were recruited into the study. Blood samples were withdrawn 5 min before and 24 h after the blood donation. Serum nitric oxide, malondialdehyde levels, and activity of superoxide dismutase and myeloperoxidase were measured spectrophotometrically. Serum levels of high-sensitive C-reactive protein and pentraxin-3 as acute-phase reactants were measured by enzyme-linked immunosorbent assay kits. We found statistically significant lower pentraxin-3 and high-sensitive C-reactive protein levels and higher superoxide dismutase activity and nitric oxide level 24 h after blood donation in serum of blood donor when compared with before blood donation. These findings suggest that blood donation affected oxidative status and acute-phase reactants in donors. Blood donation removes oxidants and decreases oxidative stress by elevating antioxidant enzyme such as superoxide dismutase. This is one more health benefit or reason why we should donate blood. Further large-scale studies should evaluate this mechanism and compare the same effect of wet cupping therapy. © 2017 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1515/jbcpp-2015-0111
dc.identifier.endpage657
dc.identifier.issn0792-6855
dc.identifier.issn2191-0286
dc.identifier.issue6
dc.identifier.pmid27089416
dc.identifier.scopus2-s2.0-84994065785
dc.identifier.scopusqualityQ3
dc.identifier.startpage653
dc.identifier.urihttps://doi.rog/10.1515/jbcpp-2015-0111
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3163
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter de Gruyter GmbH info@degruyter.com
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectacute-phase reactants
dc.subjectblood donation
dc.subjectmalondialdehyde
dc.subjectsuperoxide dismutase
dc.titleOne more health benefit of blood donation: Reduces acute-phase reactants, oxidants and increases antioxidant capacity
dc.typeArticle

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