The Role of ADAMTS9 Gene Promoter (Ca) Repeat in Developmental Hip Dysplasia

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dc.authoridacar, muradiye/0000-0003-4357-5229|Yilmaz, Ayse Esra/0000-0002-9671-749X
dc.contributor.authorYilmaz, Ayse E.
dc.contributor.authorAtalar, Hakan
dc.contributor.authorAcar, Muradiye
dc.contributor.authorDogan, Mikail
dc.contributor.authorAytekin, Mahmut N.
dc.contributor.authorGunduz, Mehmet
dc.contributor.authorGunduz, Esra
dc.date.accessioned2025-10-24T18:10:31Z
dc.date.available2025-10-24T18:10:31Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: The relationship between the number of cytosine-adenine base pair repetition [(CA)n] in the promoter zone of ADAMTS9 gene, which may affect the collagen structure, and the developmental hip dysplasia was investigated. Methods: Using DNA isolating from 26 patients diagnosed with developmental hip dysplasia (DDH) and 29 patients without DDH, the (CA) n in the promoter zone of ADAMTS9 was calculated. The distributions of groups were measured by Shapiro-Wilk test, and the average results of the groups in the state of their normal distributions were compared using parametric Student t test. Results: While the (CA) n values varied between 15 and 30, the group average was found to be 17.9. While the (CA) n values of the patient group varied between 11 and 20, its average was computed to be 17.3. The averages of groups were not statistically different (p = 0.960). Conclusion: According to the results of our study, AD-AMTS9 gene promoter (CA)n in the individuals with developmental hip dysplasia was not found to be different from that of healthy individuals. Nevertheless, when strong impact of ADAMTS9 gene on the ligament tissue is considered, it is necessary to evaluate ADAMTS9 gene role with different aspects.
dc.identifier.endpageE217
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84939203067
dc.identifier.scopusqualityQ2
dc.identifier.startpageE213
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4237
dc.identifier.volume38
dc.identifier.wosWOS:000359119100012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigation
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCongenital Dislocation; Cartilage; Ultrasonography
dc.titleThe Role of ADAMTS9 Gene Promoter (Ca) Repeat in Developmental Hip Dysplasia
dc.typeArticle

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