The Effect of Varying Doses of Intravenous Paracetamol on the Electrical Activity of the Brain in Penicillin-Induced Status Epilepticus in Rats

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dc.contributor.authorMumcuoglu, Ibrahim
dc.contributor.authorKurt, Semiha
dc.contributor.authorAydin, Duygu
dc.contributor.authorEkici, Fatih
dc.contributor.authorKasap, Zeynep
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorAygun, Hatice
dc.date.accessioned2025-10-24T18:10:10Z
dc.date.available2025-10-24T18:10:10Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: Paracetamol is a widely used analgesic and antipyretic agent. It has been reported that N-arachidonoyl-phenolamine, the active metabolite of paracetamol, reduces epilepsy by activating the endocannabinoid system in some models of experimental epilepsy. Diazepam is a benzodiazepine well known to have anticonvulsant effects. The aim of the present study was to investigate the effects of different doses of paracetamol on penicillin-induced epileptiform activity (PIEA) in rats. Methods: Rats anesthetized with urethane (1.25 g/ kg, intraperitoneal) were placed in a stereotaxic frame. Body temperatures were maintained at 37 degrees C by a heating blanket. An epileptic focus was produced by 500 IU Penicillin G (PGP) injection into the soma-motor cortex using a hole drilled into the cranium. Paracetamol (100, 150 and 300 mg/ kg, respectively) and diazepam (5 mg/ kg) were administered thirty minutes after PGP injection, and their effects on the epileptiform activity were examined comparatively. Electrocorticographic activity was monitored for two hours. Results: Intracortical injection of PGP (500 units) induced epileptiform activity in all groups of rats. Diazepam caused a statistical significant decrease in the epileptiform activity in the 40th minute after PGP injection. Paracetamol (100 mg/ kg) application did not influence the PIEA (p> 0.05). However, 150 and 300 mg/ kg IV paracetamol had a statistically significant effect on the antiepileptic activity (p< 0.001). Conclusion: The results of the present study indicated that 150 and 300 mg/ kg doses of paracetamol had an effect on PIEA. Further studies are needed to understand the reasons for this effect.
dc.identifier.doi10.5505/epilepsi.2015.30085
dc.identifier.endpage19
dc.identifier.issn1300-7157
dc.identifier.issue1
dc.identifier.startpage13
dc.identifier.trdizinid176139
dc.identifier.urihttps://doi.org/10.5505/epilepsi.2015.30085
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/176139
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4020
dc.identifier.volume21
dc.identifier.wosWOS:000408858800003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofEpilepsi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAcetaminophen; diazepam; epilepsy; paracetamol; penicillin
dc.titleThe Effect of Varying Doses of Intravenous Paracetamol on the Electrical Activity of the Brain in Penicillin-Induced Status Epilepticus in Rats
dc.typeArticle

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