Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case-control study

dc.authorid0000-0001-7937-4141en_US
dc.contributor.authorGörkem,Ü., Yıldırım,E.
dc.date.accessioned2022-03-14T10:12:49Z
dc.date.available2022-03-14T10:12:49Z
dc.date.issued21 ocak 2022en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: There is scant evidence concerning the relationship of alarin concentrations for polycystic ovary syndrome (PCOS) status in the existing literature. Therefore, we aimed to reveal the relationship about predictive value of serum alarin concentrations for PCOS risk in infertile women. Methods: This prospective case–control study included a total of 151 infertile women who met eligibility criteria of the study. Infertile women diagnosed with PCOS formed the study group (n = 80). Women with diagnoses of unexplained infertility constituted the control group (n = 71). The biochemical analyses of serum concentrations of lipid profiles, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH) and alarin were performed. Results: There were no differences for the study parameters, including age, body mass index, fasting glucose, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total triglyceride, E2, and FSH levels in either group. Serum LH, AMH, alarin concentrations, and antral follicle counts had higher values in the PCOS group compared with the controls. Correlation analysis revealed that serum alarin levels were significantly positively correlated with LH and AMH levels, only in the PCOS group. Multivariate binary logistic regression analysis demonstrated that infertile women with high alarin concentrations were significantly more likely to develop PCOS (OR = 1.77, 95% CI = 0.095–0.332, p < 0.001). Conclusion: Higher serum concentrations of alarin and a positive correlation with serum LH levels were found in infertile women with PCOS. This evidence supported that high alarin concentrations might play a role in the development of PCOSen_US
dc.identifier.citationGörkem,Ü., Yıldırım,E. Alarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case–control study,J. Obstet. Gynaecol. Res. 2022,doi:10.1111/jog.15176en_US
dc.identifier.doi10.1111/jog.15176
dc.identifier.endpage7en_US
dc.identifier.pmid35174578
dc.identifier.scopus2-s2.0-85124583369en_US
dc.identifier.startpage1en_US
dc.identifier.uridoi:10.1111/jog.15176
dc.identifier.urihttps://hdl.handle.net/20.500.12899/624
dc.identifier.wosWOS:000756062700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYıldırım, Engin
dc.language.isoenen_US
dc.publisherwileyen_US
dc.relation.ispartofJ. Obstet. Gynaecol. Res.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalarinen_US
dc.subjectinfertilityen_US
dc.subjectluteinizing hormoneen_US
dc.subjectpolycystic ovary syndromeen_US
dc.titleAlarin: A new predictive marker in infertile women with polycystic ovary syndrome: A case-control studyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
engin yıldırım,2022.pdf
Boyut:
193.47 KB
Biçim:
Adobe Portable Document Format
Açıklama:
makale dosyası
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama: