Proconvulsant Effect of NUCB2/Nesfatin-1

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dc.authoridErken, Haydar Ali/0000-0003-0103-4096|Ayada, Ceylan/0000-0002-6272-4173|Erken, Gulten/0000-0001-9234-7762|Turgut, Gunfer/0000-0002-6329-4398|Turgut, Sebahat/0000-0002-7884-5623|Turgut, Sebahat/0000-0002-7629-2631
dc.contributor.authorErken, Haydar Ali
dc.contributor.authorKoc, Emine Rabia
dc.contributor.authorErken, Gulten
dc.contributor.authorGenc, Osman
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorGokce, Emre Cemal
dc.contributor.authorAyada, Ceylan
dc.date.accessioned2025-10-24T18:08:50Z
dc.date.available2025-10-24T18:08:50Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractNUCB2/nesfatin-1 has been implicated in various physiological functions such as feeding, drinking and the sleep-wake cycle, but its effect on epileptic activity is not clear. The aim of this study was to investigate the effects of NUCB2/nesfatin-1 on penicillin-induced epileptic activity and to answer the question of whether only NUCB2/nesfatin-1 cause epileptic activity in rats. Thirty-five rats were randomly assigned to the following seven groups: control, saline, penicillin, two different doses of NUCB2/nesfatin-1 (100 and 300 pmol), penicillin and two different doses of NUCB2/nesfatin-1 (100 and 300 pmol). EEGs were recorded before the injections and during the following 120 min. The EEG and motor findings of epileptic seizures were observed in NUCB2/nesfatin-1-injected groups. NUCB2/nesfatin-1 significantly increased the EEG power spectrum, spike frequency and amplitude values in penicillin-induced epileptic rats. These findings indicate that NUCB2/nesfatin-1 both causes epileptic activity and increases penicillin-induced epileptic activity in rats.
dc.identifier.doi10.1007/s10989-014-9428-6
dc.identifier.endpage38
dc.identifier.issn1573-3149
dc.identifier.issn1573-3904
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84933041744
dc.identifier.scopusqualityQ2
dc.identifier.startpage29
dc.identifier.urihttps://doi.org/10.1007/s10989-014-9428-6
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3334
dc.identifier.volume21
dc.identifier.wosWOS:000348448700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal Of Peptide Research And Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectEEG; Epilepsy; Nesfatin-1; NUCB2; Seizure
dc.titleProconvulsant Effect of NUCB2/Nesfatin-1
dc.typeArticle

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