A current method in gynecological cancer prediction: "Micronucleus": Review
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S. aysea@turkiyeklinikleri.com Turkocagi Caddesi No. 30 Balgat 06520
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Prediction and early diagnosis of cancer are vital in gynecology. Studies have shown that both micronucleus (MN) and micronucleus tests (MNT)s can be used to predict cancers. Approximately 92% of all of the human malignancies occur in epithelial tissues. The MN assay in exfoliated cells is an innovative genotoxicity technique which holds promise for the study of epithelial carcinogens. Micronuclei are usually produced during the metaphase/anaphase transition of mitosis. If the process of cell division is disturbed, the sharing of the genetic material to the two daughter nuclei may be affected. The same situation will also occur if the chromosomes are broken or damaged by radiation, drugs and chemicals. Under these conditions, the genetic materials that are not included in the nuclei of the daughter cells will then form its own "micronucleus". A MNT is a special toxicological test that is usually employed in screening chemical compounds that are potentially genotoxic. The main objective of the test is to identify those genotoxic agents, which are capable of modifying the structure and segregation of chromosomes, in a specific way that enables the induction of micronuclei in interphase cells. MNT is used to determine carcinogenic agents that are capable of triggering off a specific type of cytogenetic damage, which lead to the formation of micronuclei containing lagging chromosome fragments or whole chromosomes. Recently MNT began to be used in gynecology and will be one of the most important parameter in prediction, prognoses and response to treatment of cancer in the near future. © 2018 Elsevier B.V., All rights reserved.
Açıklama
Anahtar Kelimeler
Early detection of cancer, Micronucleus tests, Uterine cervical neoplasms
Kaynak
Turkiye Klinikleri Jinekoloji Obstetrik
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
26
Sayı
3
