The Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats

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dc.contributor.authorCarlioglu, Ayse
dc.contributor.authorAkdeniz, Derya
dc.contributor.authorAlkan, Rabia
dc.contributor.authorUz, Ebru
dc.contributor.authorHaltas, Hacer
dc.contributor.authorTurgut, Faruk
dc.contributor.authorUysal, Sema
dc.date.accessioned2025-10-24T18:10:09Z
dc.date.available2025-10-24T18:10:09Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOBJECTIVE: Oxidative stress is responsible for some important complications of diabetes mellitus. Zofenopril, which has an antioxidant effect, may decrease the oxidative stress of the diabetic microenvironment. The aim of our study was to evaluate the effect of zofenopril in the liver, pancreas and kidney of alloxan- induced diabetic rats. MATERIAL and METHODS: Rats were divided into five groups: control group (n=6), rats treated with zonenopril (50 mg/kg/day, orally four weeks; n=6), rats exposed to alloxane (120 mg/kg single dose intraperitoneal injection, n=6), rats administered alloxan+ zofenopril (n=6) and rats administered insulin plus alloxan. RESULTS: After one month, we observed histological improvement in the kidneys but not in the pancreas and liver. CONCLUSION: In conclusion, zofenopril may be effective on the renal complications of diabetes mellitus.
dc.identifier.doi10.5262/tndt.2014.1002.07
dc.identifier.endpage124
dc.identifier.issn1300-7718
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84901458640
dc.identifier.scopusqualityN/A
dc.identifier.startpage118
dc.identifier.urihttps://doi.org/10.5262/tndt.2014.1002.07
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3999
dc.identifier.volume23
dc.identifier.wosWOS:000217184600007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisi
dc.relation.ispartofTurkish Nephrology Dialysis And Transplantation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectZofenopril; Alloxan; Diabetes; Morphological changes; Antioxidant effect; Rat
dc.titleThe Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats
dc.title.alternativeDiyabetik ratlarda karaci?er, böbrek ve pankreas hasarinda zofenoprilin etkisi
dc.typeArticle

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