Simultaneous analysis of biochemical markers in vitreous humour and serum: a preliminary study on the effect of storage time at -20°C

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dc.authoridKarapirli, Mustafa/0000-0001-5735-9960;
dc.contributor.authorGurler, Mukaddes
dc.contributor.authorOzturk, Gulfer
dc.contributor.authorKir, M. Ziya
dc.contributor.authorGinis, Zeynep
dc.contributor.authorErden, Gonul
dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorKaya, Mehmet
dc.date.accessioned2025-10-24T18:09:13Z
dc.date.available2025-10-24T18:09:13Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractVitreous humour (VH) is a quite stable and well-protected biological fluid from post-mortem degradation and contamination, making it a usable specimen in forensic pathology. We aimed to analyse the biochemical markers in VH stored for one month at -20 degrees C and to compare them with those of serum samples of the same deceased people. To the best of our knowledge this is the first time this has been reported in the literature. Serum levels of sodium, potassium and calcium, phosphorous and VH levels of calcium, creatinine, and urea were not statistically different between fresh and stored samples. There was no significant difference in VH urea and creatinine levels whereas serum levels were significantly decreased by the 15th and 30th days. In conclusion, urea and creatinine levels in VH showed adequate stability after one month of storage at -20 degrees C, whereas large variations were seen in the stability of inorganic components such as Na, K, Mg, Cl, and P. Our results indicate the validity of using post-mortem VH samples for urea and creatinine but not for VH stored at -20 degrees C for a limited time frame. The differences in sample handling before being stored at -20 degrees C may introduce bias on some components of VH.
dc.identifier.doi10.1080/00450618.2015.1042046
dc.identifier.endpage158
dc.identifier.issn0045-0618
dc.identifier.issn1834-562X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84959179034
dc.identifier.scopusqualityQ2
dc.identifier.startpage150
dc.identifier.urihttps://doi.org/10.1080/00450618.2015.1042046
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3532
dc.identifier.volume48
dc.identifier.wosWOS:000371733000005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofAustralian Journal Of Forensic Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectbiochemical markers; serum storage; vitreous humour
dc.titleSimultaneous analysis of biochemical markers in vitreous humour and serum: a preliminary study on the effect of storage time at -20°C
dc.typeArticle

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