Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome

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dc.contributor.authorAdemoğlu, Esranur
dc.contributor.authorBerberoglu, Suha
dc.contributor.authorÇarlioğlu, Ayşe Kargılı
dc.contributor.authorDellal, Fatma Dilek
dc.contributor.authorGörar, Süheyla
dc.contributor.authorAlphan, Ziynet
dc.contributor.authorUysal, Sema
dc.date.accessioned2025-10-24T18:06:51Z
dc.date.available2025-10-24T18:06:51Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe aim of this paper was to compare serum chemerin levels in nonobese and overweight/obese patients with polycystic ovary syndrome (PCOS) with lean controls. Methods. Seventy women with newly diagnosed or untreated PCOS and 38 age-matched nonobese healthy controls were enrolled in the present study. Participants with PCOS were categorized as nonobese (Body Mass Index [BMI] <25 kg/m2, N.=36) or overweight/obese (BMI 25-29.9 kg/m2 and ?30 kg/m2, respectively, N.=34). Anthropometric, metabolic and hormonal patterns, and serum chemerin were measured. Results. Serum chemerin tended to be higher in obese PCOS group than in nonobese PCOS women but did not reach statistical significance. Nonobese healthy controls had significantly lower chemerin levels than two PCOS groups (PcO.OOl). Fasting insulin (P<0.05) and homeostasis model assessment index (p<0.05) were significantly higher in obese women with PCOS than in other two groups. Also, these two parameters were higher in lean patients with PCOS than in healthy controls (p<0.05). In multiple linear regression analyses, chemerin was significantly associated with BMI (?-coefficient =0.336, p<0.01), and triglyceride (?-coefficient =0.298, p<0.05). Conclusion. Chemerin levels were significantly increased not only in obese PCOS women but also in nonobese PCOS women. The physiological significance of elevated serum chemerin in PCOS remains unclear. © 2016 Elsevier B.V., All rights reserved.
dc.identifier.endpage542
dc.identifier.issn0026-4784
dc.identifier.issn1827-1650
dc.identifier.issue6
dc.identifier.pmid25373013
dc.identifier.scopus2-s2.0-84923766244
dc.identifier.scopusqualityN/A
dc.identifier.startpage535
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3235
dc.identifier.volume66
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Minerva Medica subscriptions.dept@minervamedica.it
dc.relation.ispartofMinerva Ginecologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectChemerin, human
dc.subjectPhysiology
dc.subjectPolycystic ovary syndrome
dc.titleHigher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome
dc.typeArticle

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