Assessment of mean platelet volume (MPV) in primary hyperparathyroidism: Effects of successful parathyroidectomy on MPV levels

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dc.contributor.authorYilmaz, Hakki
dc.date.accessioned2025-10-24T18:06:45Z
dc.date.available2025-10-24T18:06:45Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective. A determinant of platelet function - mean platelet volume (MPV), is newly emerging risk factor for atherothrombosis. The aim of this study is to evaluate MPV in patients with primary hyperparathyroidism (PHPT) before parathyroidectomy (PTX) and six months after successful PTX in a retrospective study. Methods. We analyzed the changes in serum biochemical, parathyroid hormone (PTH) and MPV before and six months after PTX in 66 patients with PHPT and 44 healthy controls, age- and sex-matched. Results. Sixty-six patients (18 men, 48 women) with mean age 53.8±12.7 years were analyzed. MPV was significantly higher in the patients with PHPT before PTX than in the same group after PTX (9.26±1.20 fl vs. 7.99±0.80 fl, p<0.0001). MPV levels were positively correlated with PTH (r=0.888, p<0.0001), calcium (r=0.292, p=0.017) in the preoperative phase. Postoperative (after 6 months) MPV showed a significant positive correlation with postoperative PTH (r=0.381, p=0.002) and calcium levels (r=0.324, p=0.008). Conclusions. These results suggest that subjects with PHPT lead to have increased platelet activation. © 2015 Elsevier B.V., All rights reserved.
dc.identifier.doi10.4149/endo_2014_04_182
dc.identifier.endpage188
dc.identifier.issn1336-0329
dc.identifier.issn1210-0668
dc.identifier.issue4
dc.identifier.pmid25512191
dc.identifier.scopus2-s2.0-84928636454
dc.identifier.scopusqualityQ3
dc.identifier.startpage182
dc.identifier.urihttps://doi.rog/10.4149/endo_2014_04_182
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3190
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInstitute of Experimental Endocrinology ueenregu@kramare.savba.sk
dc.relation.ispartofEndocrine Regulations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectCured parathyroidectomy
dc.subjectMPV
dc.subjectPrimary hyperparathyroidism
dc.subjectPTH
dc.titleAssessment of mean platelet volume (MPV) in primary hyperparathyroidism: Effects of successful parathyroidectomy on MPV levels
dc.typeArticle

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