The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer

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dc.authoridSari, Ismail/0000-0003-3732-2102;
dc.contributor.authorHasbek, Zekiye
dc.contributor.authorDogan, Omer Tamer
dc.contributor.authorSan, Ismail
dc.contributor.authorYucel, Birsen
dc.contributor.authorSeker, Mehmet Metin
dc.contributor.authorTurgut, Bulent
dc.contributor.authorBerk, Serdar
dc.date.accessioned2025-10-24T18:09:59Z
dc.date.available2025-10-24T18:09:59Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Mutations in the p53 gene are the most commonly observed genetic abnormalities in malignancies. The purpose of this study was to assess the diagnostic value of serum anti-p53 antibody (Ab) along with the correlation between serum anti-p53 Ab level and quantitative positron emission tomography (PET) parameters such as maximum standardized uptake value (SUVmax), SUVave, metabolic tumor volume, total lesion glycolysis (TLG) and tumor size. Methods: Serum anti-p53 Ab level was studied in three groups. Patients who underwent F-18-fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging for staging of previously diagnosed lung cancer constituted the first group, while patients who underwent F-18-FDG PET/CT imaging for evaluation of suspicious pulmonary nodules detected on thorax CT and did not show pathologic FDG accumulation (NAPN= pulmonary nodule with non avid-FDG) were enrolled in the second group. The third group consisted of healthy volunteers. Results: Twenty-eight patients with lung cancer (median age: 62.5, range: 39-77years), 28 patients with NAPN (median age: 65, range: 33-79 years), and 24 healthy volunteers (median age: 62, range: 44-74 years) were enrolled in the study. The serum anti-p53 Ab level was low in healthy volunteers while it was higher in both lung cancer patients and NAPN patients (p< 0.05). When serum anti-p53 Ab level and PET parameters were evaluated, there was no significant correlation between serum anti-p53 Ab level and SUVmax, SUVave, TLG, tumor volume and tumor size of patients with lung cancer (p> 0.05). Besides, there was no significant difference between serum anti-p53 Ab level and lesion size of NAPN patients (p> 0.05). Conclusion: It was determined that serum anti-p53 Ab levels are not significantly correlated with PET parameters, and that serum anti-p53 Ab levels increase in any benign or malignant lung parenchyma pathology as compared to healthy volunteers. These results indicate that this Ab cannot be used as a predictor of malignancy in a lung lesion.
dc.description.sponsorshipCumhuriyet University Scientific Research Project Unit [T-597]
dc.description.sponsorshipThe work was supported by grants from Cumhuriyet University Scientific Research Project Unit (T-597).
dc.identifier.doi10.4274/mirt.97269
dc.identifier.endpage113
dc.identifier.issn2146-1414
dc.identifier.issn2147-1959
dc.identifier.issue3
dc.identifier.pmid27751972
dc.identifier.startpage107
dc.identifier.urihttps://doi.org/10.4274/mirt.97269
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3919
dc.identifier.volume25
dc.identifier.wosWOS:000391387000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofMolecular Imaging And Radionuclide Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAnti-p53 antibody; lung cancer; fluorodeoxyglucose; positron emission tomography/computed tomography
dc.titleThe Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer
dc.typeArticle

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