Can myocardial dysfunction be detected in patients with rheumatoid arthritis with no cardiac symptoms?
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Publisher
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: The aim of our study was to investigate the role of tissue Dop-pler and Myocardial Performance Index (MPI) in evaluating cardiac involvement in patients with rheumatoid arthritis (RA) with no cardi-ac symptoms, to determine whether these mea-surements differ between healthy controls and RA patients, and whether they can be used to determine the risk of cardiovascular disease and predict prognosis.PATIENTS AND METHODS: 50 RA patients fulfilling the 2010 American College of Rheuma-tology/European League Against Rheumatism (ACR/EULAR) RA criteria and 50 healthy volun-teering controls were included in the study. All patients and controls were assessed using elec-trocardiography (ECG), echocardiography, con-ventional Doppler echocardiography and tissue Doppler echocardiography. MPI values were cal-culated. In addition, RA patients were compared after being divided into two subgroups: sero-positive and seronegative RA. Disease activi-ty levels of the patients were determined based on Disease Activity Score in 28 Joints (DAS28).RESULTS: The control group and RA group were compared in terms of PR interval, left atrial diameter, E/A, E/e', and MPI values. Comparisons between the groups yielded statistically signifi-cant differences in left atrial diameter, E/A, E/e', and MPI values and no significant difference in PR intervals. These parameters were also com-pared between seropositive and seronegative pa-tients. Left atrial diameter was significantly high-er in seronegative patients than in seropositive patients. There was no significant difference in the other values. DAS28 scores had no correla-tion with cardiac parameters.CONCLUSIONS: Early detection of ventricu-lar dysfunction in RA may be useful in clinical practice when predicting prognosis and optimiz-ing treatment. The present study found that RA patients had impaired tissue Doppler measure-ments and MPI results compared to controls. MPI and tissue Doppler may be useful in early detection of ventricular dysfunction.
Açıklama
Anahtar Kelimeler
Rheumatoid arthritis; Myocardial performance in-dex (MPI); Tissue doppler
Kaynak
European Review For Medical And Pharmacological Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
27
Sayı
10
