Delta Neutrophil Index as a Diagnostic Marker of Neonatal Sepsis

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dc.authorid0000-0002-3491-2337en_US
dc.contributor.authorMelekoğlu, Nuriye Aslı
dc.contributor.authorYaşar, Şeyma
dc.contributor.authorKeskin, Mehmet
dc.date.accessioned2021-09-13T11:52:21Z
dc.date.available2021-09-13T11:52:21Z
dc.date.issued2021en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective Sepsis diagnosis is challenging due to nonspecific symptomatology in newborns. Timely diagnosis is essential for reducing sepsis-related morbidity and mortality. This study was performed to determine the diagnostic value of the delta neutrophil index (DNI) for detection of neonatal sepsis and to compare its efficacy with other conventional markers. Methods This study was conducted at a tertiary hospital in newborns with confirmed sepsis (n = 59), suspected sepsis (n = 46), and in age- and weight-matched controls (n = 49). DNI, white blood cell count, C-reactive protein (CRP) level, and platelet measurements were determined, and blood cultures were performed at the onset of symptoms. Results The mean DNI was significantly higher in confirmed and clinical sepsis groups compared with the control group. (6.9 ± 9.3, 1.9 ± 2.1, and 0.4 ± 0.5, respectively, p < 0.001). ROC curve analysis also showed that the combination of DNI and CRP had the highest sensitivity (86%), specificity (100%), and positive predictive value (100%) for predicting neonatal sepsis. DNI values were significantly higher in nonsurvivors (p < 0.05). Conclusion DNI could be used as a reliable diagnostic marker for neonatal sepsis, and high DNI could predict sepsis development and unfavorable outcomes. The diagnostic capability of DNI may be increased by assessing CRP measurements simultaneously.en_US
dc.identifier.citationMelekoglu, N. A., Yasar, S., & Keskin, M. (2021). Delta Neutrophil Index as a Diagnostic Marker of Neonatal Sepsis. Journal of Pediatric Infectious Diseases, 16(03), 99-105.en_US
dc.identifier.doi10.1055/s-0041-1726118
dc.identifier.endpage105en_US
dc.identifier.issn1871-0336en_US
dc.identifier.issn1305-7707en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85101883782en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/ 10.1055/s-0041-1726118
dc.identifier.urihttps://hdl.handle.net/20.500.12899/409
dc.identifier.volume16en_US
dc.identifier.wosWOS:000621594600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorMelekoğlu, Nuriye Aslı
dc.language.isoenen_US
dc.publisherIOS Pressen_US
dc.relation.ispartofIOS Pressen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDelta neutrophil indexen_US
dc.subjectSepsisen_US
dc.subjectNewbornen_US
dc.titleDelta Neutrophil Index as a Diagnostic Marker of Neonatal Sepsisen_US
dc.typeArticleen_US

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