High-fat and carbohydrate diet caused chronic kidney damage by disrupting kidney function, caspase-3, oxidative stress and inflammation

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072;
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorKayhan, Elif
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorErdemli, Mehmet Erman
dc.date.accessioned2025-10-24T18:09:10Z
dc.date.available2025-10-24T18:09:10Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe study aimed to compare the effects of a diet rich in fat, carbohydrates and protein on rat kidneys. The study was conducted on 40 Wistar albino rats bred at Ino center dot nu University Faculty of Medicine after the approval of the ethics committee. Rats were randomly divided into 4 groups: Control group, and the groups where the animals were fed with high carbohydrate, fat and protein rich feed. After the applications, the rat kidney tissues were removed by laparoscopy under anesthesia and blood samples were collected. 13 weeks long fat-rich and carbohydrate feed application had negative effects on oxidant-antioxidant balance, oxidative stress index, inflammation markers, kidney functions tests, histopathology and immunohistochemistry caspase-3 findings in rat kidney tissues, especially in the carbohydrate group when compared to the controls. Protein-rich feed, there were no significant difference in biochemical and histopathology compared to the control group. Fat and carbohydrate rich feed led to an increase in oxidative stress in rat kidney tissues. Oxidative stress led to nephrotoxicity, which in turn led to chronic kidney tissue damages. A more balanced and protein-rich diet instead of excessive sugar and fatty food intake could be suggested to prevent chronic kidney damage.
dc.identifier.doi10.1016/j.prostaglandins.2024.106822
dc.identifier.issn1098-8823
dc.identifier.issn2212-196X
dc.identifier.pmid38395139
dc.identifier.urihttps://doi.org/10.1016/j.prostaglandins.2024.106822
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3481
dc.identifier.volume172
dc.identifier.wosWOS:001199998900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofProstaglandins & Other Lipid Mediators
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectHigh fat diet; High carbohydrate diet; High protein diet; Chronic kidney disease; Oxidative stress; Inflammation
dc.titleHigh-fat and carbohydrate diet caused chronic kidney damage by disrupting kidney function, caspase-3, oxidative stress and inflammation
dc.typeArticle

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