Relation between abdominal subcutaneous fat tissue thickness and inflammatory markers during pregnancy

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dc.authoridKosus, Nermin/0000-0003-2390-9498
dc.contributor.authorKosus, Nermin
dc.contributor.authorKosus, Aydin
dc.contributor.authorTurhan, Nilgun
dc.date.accessioned2025-10-24T18:10:02Z
dc.date.available2025-10-24T18:10:02Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntroduction: Subcutaneous abdominal fat thickness (SCFT) is important for predisposition to metabolic and cardiovascular diseases. Our aim was to evaluate maternal SCFT and metabolic changes (such as insulin resistance and high inflammatory markers) during pregnancy. Material and methods: A total of 92 pregnant women between 24-28 weeks of gestation were enrolled in the study. The SCFT was measured by ultrasonography and patients were divided into 2 groups according to thickness of maternal SCFT and body mass index (BMI). Groups were compared with each other for oral glucose loading test (OGL) results, and for haematological, biochemical and fetal biometric parameters. Results: After analysis of frequency for SCFT, the most appropriate cut-off value for grouping patients was found to be 15 mm for SCFT. In 48 cases SCFT was over 15 mm. High C reactive protein (CRP) was found in 47.9% (23) of cases with SCFT over 15 mm. Serum haemoglobin A(1c) (HbA(1c)) level was significantly correlated with SCFT thickness. The most important factors for determination of OGL level were found to be serum HbA(1c) level, BMI and SCFT In obese subjects (BMI >= 25 kg/m(2)), levels of inflammatory markers and SCFT thickness were higher. The CRP and gamma-glutamyltransferase (GGT) levels were significantly correlated with BMI and SCFT. Conclusions: High SCFT during pregnancy is associated with elevated inflammatory marker levels and HbA(1c). Pregnant women with thicker SCFT may be susceptible to the development of metabolic complications of pregnancy, such as gestational diabetes mellitus (GDM) and hypertension, as well as risk of future metabolic and cardiovascular disease.
dc.identifier.doi10.5114/aoms.2014.44865
dc.identifier.endpage745
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue4
dc.identifier.pmid25276159
dc.identifier.startpage739
dc.identifier.urihttps://doi.org/10.5114/aoms.2014.44865
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3957
dc.identifier.volume10
dc.identifier.wosWOS:000341274400015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives Of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectpregnancy; adipose tissue; inflammation; subcutaneous fat tissue
dc.titleRelation between abdominal subcutaneous fat tissue thickness and inflammatory markers during pregnancy
dc.typeArticle

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