An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity

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Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Ondokuz Mayıs University

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Acrylamide is an organic compound that is known to have neurotoxic influences. People have high exposure to its impacts because of its extensive uses in the industrial fields and its occurrence in foods. This situation has induced the scientific word to identify naturel components that may eliminate these neurotoxic effects. In this experimental study the influence of black carrot juice containing bioavailable flavonoids was researched on acrylamide neurotoxicity. In the study, laboratory rats were divided in to four groups. Group 1 rats were the control group. While the rats in Group 2 were administered acrylamide substance, the rats in Group 3 were supplemented with black carrot juice + acrylamide, and the rats in Group 4 were given black carrots juice only. At the experiment’s end, biochemical, histopathological, and histomorphometry analysis were performed on exanguned rats. Significant histopathological degenerations were observed in the acrylamide treated group. Despite a volumetric degrease in all brain regions examined histomorphometrically, this decrease was not statistically significant. The malondialdehyde and Glutathione S-transferase levels of the acrylamide group showed a significant increase compared to the control group. The glutathione, carboxylesterase and acetylcholinesterase levels were observed to increase in the acrylamide and black carrot applied group, compared to the acrylamide group. This study’s findings have revealed the black carrot’s healing effects on acrylamide neurotoxicity.

Açıklama

Anahtar Kelimeler

Acrylamide, Neurotoxicity, Black Carrot, Histopathology, Morphometry

Kaynak

Journal of Experimental and Clinical Medicine

WoS Q Değeri

Scopus Q Değeri

Q4

Cilt

38

Sayı

2

Künye

Esen, G., Uçkun, M., Özkaya, A., Yoloğlu, E., Annaç, E., Pekmez, H., Uludağ, S. (2021). An investigation of histopathologic and morphometric effect of black carrot juice on acrylamid induced neurotoxicity . Journal of Experimental and Clinical Medicine, 38 (2), 82-87. Retrieved from https://dergipark.org.tr/en/pub/omujecm/issue/61150/845744