Association among ABCA7 Gene Polymorphism, rs3764650 and Alzheimer's Disease in the Turkish Population

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dc.contributor.authorOznur, Murat
dc.contributor.authorHatipoglu, Omer F.
dc.contributor.authorAyturk, Zubeyde
dc.contributor.authorDede, Serap
dc.contributor.authorAkbas, Kubra
dc.contributor.authorAydin, Duygu
dc.contributor.authorUrhan, Ayse
dc.date.accessioned2025-10-24T18:10:29Z
dc.date.available2025-10-24T18:10:29Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Alzheimer's disease (AD), the most common form of dementia, is an irreversible and progressive neurodegenerative disease that is characterized by the progressive loss of cognitive functions, behavioral and psychological disorders and a decrease in daily routine activities. Among people aged 65 years and over, AD is steadily increasing. Genome-wide association studies have shown that various gene polymorphisms are highly associated with the pathogenesis of AD. Among them, ABCA7 gene polymorphism has been identified as one of the genetic risks. The purpose of this study was to investigate the relationship among ABCA7 gene polymorphism, rs3764650 and AD, and to determine if it could be use as a biomarker for AD susceptibility in the Turkish population. Methods: Peripheral blood samples of 54 Alzheimer's patients and 57 control subjects were collected. Genomic DNA was isolated by SDS/proteinase K treatment followed by phenolchloroform extraction and ethanol precipitation. The presence of the ABCA7 gene rs3764650 polymorphism was investigated by PCR-RFLP and selected samples were confirmed by DNA sequencing. Results: In the Turkish population, the ABCA7 gene rs3764650 polymorphism did not show a significant association with AD when compared with the control group (p>0.05). APOE-epsilon 3 allele frequencies were higher in both AD patients and control subjects (76.85% and 84.21%, respectively). Conclusion: Both previously published studies and our current study did not cover the complete genetic variation in the gene. To detect variants that are disease-related, studies with larger sample sizes are needed.
dc.identifier.endpageE192
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84939143682
dc.identifier.scopusqualityQ2
dc.identifier.startpageE187
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4192
dc.identifier.volume38
dc.identifier.wosWOS:000359119100006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigation
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCommon Variants; Cd2ap; Epha1; Cd33
dc.titleAssociation among ABCA7 Gene Polymorphism, rs3764650 and Alzheimer's Disease in the Turkish Population
dc.typeArticle

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