Ameliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity

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dc.authoridOZSOY, Eda Nur/0000-0003-4249-5024|Gozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorKayhan, Elif
dc.contributor.authorDemircigil, Nursena
dc.contributor.authorOzsoy, Eda Nur
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2025-10-24T18:09:11Z
dc.date.available2025-10-24T18:09:11Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractFirst in the literature this study aimed to investigate the effects of Tartrazine, a common industrial food dye, on kidney and whether Thymoquinone has a protective effect in tartrazine-induced nephrotoxicity. The study conducted on the rats bred at I(center dot)non & uuml; University Experimental Animals Production and Research Center. Wistar albino rats were randomly divided into 4 groups, where each group included 8 rats: control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone groups. The experiments continued for 3 weeks and then, kidney tissues and blood samples were collected from the rats under anesthesia. Malondialdehyde (MDA), super oxidized dismutase (SOD), total oxidant status (TOS), increase in Oxidative stress index (OSI), glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase (CAT), Total antioxidant status (TAS) levels decreased in the kidney tissues collected from the tartrazine group. Serum Bun and Creatinine levels increased in the tartrazine group. Tartrazine administration damaged and degenerated the glomeruli and cortical distal tubes in the histopathology of kidney tissues, also different degrees of inflammatory cell infiltration were observed in the renal cortex and medulla. Thymoquinone and tartrazine administration improved both biochemical and histopathological parameters. Tartrazine administration induced nephrotoxicity. This could be observed with the increase in oxidant capacity and the deterioration of kidney functions. Thymoquinone was observed to demonstrate strong antioxidant properties. Thymoquinone could be used primarily as a protective agent against Tartrazine-induced toxicity.
dc.identifier.doi10.1016/j.toxicon.2024.107660
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid38408527
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2024.107660
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3499
dc.identifier.volume241
dc.identifier.wosWOS:001210925800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofToxicon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectTartrazine; Thymoquinone; Nephrotoxicity; Oxidative stress; Caspase 3
dc.titleAmeliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity
dc.typeArticle

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