A comparative study of Bulgarian and Turkish Asphodeline lutea root extracts: HPLC-UV profiles, enzyme inhibitory potentials and anti-proliferative activities against MCF-7 and MCF-10A cell lines

Basit Öğe Kaydı
dc.authoridCeylan, Ramazan/0000-0002-7795-8482|acar, muradiye/0000-0003-4357-5229|Bender, Onur/0000-0003-0691-3508|Gevrenova, Reneta/0000-0002-1254-2419|Zengin, Gokhan/0000-0001-6548-7823|Zheleva-Dimitrova, Dimitrina/0000-0002-1952-9903
dc.contributor.authorLazarova, Irina
dc.contributor.authorZengin, Gokhan
dc.contributor.authorBender, Onur
dc.contributor.authorZheleva-Dimitrova, Dimitrina
dc.contributor.authorUysal, Sengul
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorGevrenova, Reneta
dc.date.accessioned2025-10-24T18:09:04Z
dc.date.available2025-10-24T18:09:04Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAsphodeline lutea (L.) Rchb. is a wild plant traditionally used as a food in the Mediterranean region. The alcoholic extracts of A. lutea roots from different origins (Bulgarian and 'Rakish) were investigated for anti-cholinesterase, anti-tyrosinase, anti-amylase, anti-glycosidase and anti-proliferative activity (against MCF-7 and MCF-10A cell lines). A validated HPLC method for the determination of two anthraquinones, two bianthraquinones, two naphthalenes, two flavonoids and one hydroxycinnamic acid was developed due to the presence of these components in the genus Asphodeline. In addition, total anthraquinones content was determined spectrophotometrically. A. lutea from Bulgaria demonstrated higher level of total anthraquinones (0.81 +/-0.05 mg g(-1)). A naphthalene derivative (2-acetyl-1,8-dimethoxy-3-methylnaphthalene) was the major compound in Bulgarian accession (0.96 +/- 0.03 mg g(-1)), while caffeic acid was the main analyte in Turkish sample (0.42 +/- 0.06 mg g(-1)). Turkish extracts were more potent as cholinesterase and tyrosinase inhibitors but less active as antidiabetic agent. The higher anti-proliferative effect was presented by Bulgarian extract with IC50 values 120 +/- 16.8 mg mL(-1) (for MCF-7) and 256 +/- 16.1 mg mL(-1) (for MCF-10A). (C) 2015 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.jff.2015.03.032
dc.identifier.endpage263
dc.identifier.issn1756-4646
dc.identifier.scopus2-s2.0-84929244585
dc.identifier.scopusqualityQ1
dc.identifier.startpage254
dc.identifier.urihttps://doi.org/10.1016/j.jff.2015.03.032
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3458
dc.identifier.volume15
dc.identifier.wosWOS:000355240800025
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal Of Functional Foods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAsphodeline lutea; Anthraquinones; Anti-cholinesterase; Anti-tyrosinase; Anti-diabetic; Anti-proliferative
dc.titleA comparative study of Bulgarian and Turkish Asphodeline lutea root extracts: HPLC-UV profiles, enzyme inhibitory potentials and anti-proliferative activities against MCF-7 and MCF-10A cell lines
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu