The investigation of the effect of chalcones with benzoic acid on xanthine oxidase activity

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dc.contributor.authorAKTAR, BEDRİYE SEDA KURSUN
dc.contributor.authorAdem, Sevki
dc.contributor.authororuç-emre, emine elçin
dc.date.accessioned2025-10-24T18:04:45Z
dc.date.available2025-10-24T18:04:45Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractInhibitors of xanthine oxidase (XO) are effective and most major therapeutic drugs for the management of gout. Chalcone compounds are important in terms of biological activity and have great importance in enzyme studies in recent years. In the presented study, the effects of some chalcones on the enzyme were tested in vitro by the spectrophotometric method. Compounds showed an inhibitory effect between 7.21±0.07 and 13.78±0.13 ?M IC50 values. The conformations and interactions of the compounds in the active site of the enzyme were determined by the molecular docking method using Molegro Virtual Docker software. Molecular modeling studies show that the B ring of chalcones has a significant contribution to the inhibition effect on the XO enzyme. The presented study suggests that chalcones may be a potential inhibitory group for XO.
dc.identifier.endpage175
dc.identifier.issn2602-277X
dc.identifier.issue2
dc.identifier.startpage170
dc.identifier.trdizinid1189332
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1189332
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3087
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofInternational Journal of Chemistry and Technology (IJCT)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectKimya
dc.subjectAnalitik
dc.subjectKimya
dc.subjectTıbbi
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectFizikokimya
dc.subjectFarmakoloji ve Eczacılık
dc.subjectKimya
dc.subjectİnorganik ve Nükleer
dc.titleThe investigation of the effect of chalcones with benzoic acid on xanthine oxidase activity
dc.typeArticle

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