The investigation of the effect of chalcones with benzoic acid on xanthine oxidase activity
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Inhibitors of xanthine oxidase (XO) are effective and most major therapeutic drugs for the management of gout. Chalcone compounds are important in terms of biological activity and have great importance in enzyme studies in recent years. In the presented study, the effects of some chalcones on the enzyme were tested in vitro by the spectrophotometric method. Compounds showed an inhibitory effect between 7.21±0.07 and 13.78±0.13 ?M IC50 values. The conformations and interactions of the compounds in the active site of the enzyme were determined by the molecular docking method using Molegro Virtual Docker software. Molecular modeling studies show that the B ring of chalcones has a significant contribution to the inhibition effect on the XO enzyme. The presented study suggests that chalcones may be a potential inhibitory group for XO.
Açıklama
Anahtar Kelimeler
Kimya, Analitik, Kimya, Tıbbi, Biyokimya ve Moleküler Biyoloji, Fizikokimya, Farmakoloji ve Eczacılık, Kimya, İnorganik ve Nükleer
Kaynak
International Journal of Chemistry and Technology (IJCT)
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
2
