Synthesis of polyhedral oligomeric silsesquioxane-n-acetylcysteine conjugate with click chemistry and ıts antioxidant response and biocompatibility

Basit Öğe Kaydı
dc.authorid0000-0001-6783-7030en_US
dc.contributor.authorKaraca Açarı, İdil
dc.contributor.authorBalcıoğlu, Sevgi
dc.contributor.authorAteş, Burhan
dc.contributor.authorKöytepe, Süleyman
dc.contributor.authorYılmaz, İsmet
dc.contributor.authorSeçkin, Turgay
dc.date.accessioned2021-06-12T18:51:36Z
dc.date.available2021-06-12T18:51:36Z
dc.date.issued2020en_US
dc.departmentMTÖ Üniversitesi, Doğanşehir Vahap Küçük Meslek Yüksekokulu, Su Ürünleri Bölümüen_US
dc.description.abstractIn this study, polyhedral oligomeric silsesquioxane-N-acetylcysteine (POSS-NAC) conjugate as a potential antioxidant molecule was synthesized from N-acetylcysteine (NAC) and aminofunctional POSS structure by click chemistry. The chemical structures and thermal properties of the synthesised POSS-NAC conjugate was characterized by spectroscopic and thermal analysis techniques. The antioxidant capacity of the POSS-NAC conjugate was also determined by the 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity and reducing power methods. According to the reducing power method, POSS-NAC structure has lower reducing activity than standard ascorbic acid and trolox (p<0.001). It was found from the ABTS radical scavenging activity results that the synthesized POSS-NAC conjugate had a significantly higher radical scavenging effect than the standards (p <0.001). Biocompatibility properties of the POSS-NAC structure were detected in vitro cell culture system with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test on L-929 mouse fibroblast cells. The synthesized POSS-NAC conjugate exhibits high antioxidant activity and good biocompatibilityen_US
dc.description.sponsorshipInonu University‘s scientific research projects unit (BAP) Project Number 2013/157en_US
dc.identifier.citationKaraca Açarı, İ., Balcıoğlu, S., Ateş, B., Köytepe, S., Yılmaz, İ., Seçkin, T. (2020). Synthesis of polyhedral oligomeric silsesquioxane-n-acetylcysteine conjugate with click chemistry and ıts antioxidant response and biocompatibility. Cumhuriyet Science Journal, 41 (2), 386-396. DOI: 10.17776/csj.688124en_US
dc.identifier.doi10.17776/csj.688124
dc.identifier.endpage396en_US
dc.identifier.issn2587-2680en_US
dc.identifier.issn2587-246Xen_US
dc.identifier.issue2en_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.17776/csj.688124
dc.identifier.urihttps://hdl.handle.net/20.500.12899/234
dc.identifier.volume41en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKaraca Açarı, İdil
dc.language.isoenen_US
dc.publisherCumhuriyet Üniversitesien_US
dc.relation.ispartofCumhuriyet Science Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolyhedral oligomeric silsesquioxane (POSS)en_US
dc.subjectN-Acetylcysteine (NAC)en_US
dc.subjectAntioxidant activityen_US
dc.subjectBiocompatibilityen_US
dc.titleSynthesis of polyhedral oligomeric silsesquioxane-n-acetylcysteine conjugate with click chemistry and ıts antioxidant response and biocompatibilityen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
İdil KARACA AÇARI-Makale Dosyası.pdf
Boyut:
948.21 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Yayın Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu