Protective Effect of Intravesical Platelet-Rich Plasma on Cyclophosphamide-Induced Hemorrhagic Cystitis

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dc.authoridYILDIRIM, MEHMET/0000-0003-4768-4537
dc.contributor.authorOzyuvali, E.
dc.contributor.authorYildirim, M. E.
dc.contributor.authorYaman, T.
dc.contributor.authorKosem, B.
dc.contributor.authorCimentepe, E.
dc.date.accessioned2025-10-24T18:10:29Z
dc.date.available2025-10-24T18:10:29Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC). Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP) and rats were randomly allocated to one of four groups (n = 6 per group): A control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1, IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, an intravesical PRP-treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia. Results: Histological evaluation showed CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but that PRP did not suppress these histopathological changes. Conclusion: PRP did not suppress the histopathological changes in rats that had IC due to cyclophosphamide injection.
dc.identifier.endpageS183
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85047593396
dc.identifier.scopusqualityQ2
dc.identifier.startpageS179
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4187
dc.identifier.volume39
dc.identifier.wosWOS:000389725000034
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigation
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectBladder Syndrome/Interstitial Cystitis; Prevention; Therapy; Rats
dc.titleProtective Effect of Intravesical Platelet-Rich Plasma on Cyclophosphamide-Induced Hemorrhagic Cystitis
dc.typeArticle

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