Thymoquinone played a protective role against tartrazine- induced

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072;
dc.contributor.authorDemircigil, Nursena
dc.contributor.authorGul, Mehmet
dc.contributor.authorGokturk, Nurcan
dc.contributor.authorKustepe, Elif Kayhan
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorErman, Mehmet
dc.date.accessioned2025-10-24T18:09:38Z
dc.date.available2025-10-24T18:09:38Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective(s): The current study, the first of its kind in the literature, aimed to observe the toxic effects of Tartrazine, a commonly used dyestuff in industries and foods, on the liver, and investigate whether this toxicity could be eliminated with thymoquinone coadministration. Materials and Methods: 32 male Wistar albino rats were procured from Inonu University Experimental Animals Breeding and Research Center. The rats were randomly assigned to 4 equal groups: Control group, Thymoquinone group, Tartrazine group, and Thymoquinone + Tartrazine group. Rat liver tissue and blood samples were obtained and biochemical and histopathological examinations were conducted on the samples. Results: Tartrazine administration increased the oxidant (malondialdehyde and superoxide dismutase) and oxidative stress index parameters (total oxidant status) in the liver tissue and decreased the antioxidant parameters (glutathione, glutathione peroxidase, catalase, and total antioxidant status) leading to histopathological problems (hematoxylin-eosin staining and Caspase-3 immunoreactivity) and inflammation (tumor necrosis factor-alpha and interleukin-6) in the serum samples. Thymoquinone, on the other hand, improved antioxidant and anti-inflammatory effects. Conclusion: At this time and dose, thymoquinone has a protective effect against tartrazine hepatotoxicity. Thymoquinone can be used as a protective agent against tartrazine toxicity.
dc.description.sponsorshipInonu University Scientific Research Fund; [TYL-2021/2441]
dc.description.sponsorshipAcknowledgment This research was supported by Inonu University Scientific Research Fund (TYL-2021/2441) . The results presented in this paper were part of a student thesis.
dc.identifier.doi10.22038/IJBMS.2022.67341.14763
dc.identifier.endpage106
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue1
dc.identifier.pmid36594061
dc.identifier.startpage99
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2022.67341.14763
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3757
dc.identifier.volume26
dc.identifier.wosWOS:000892346200013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofIranian Journal Of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectHepatotoxicity; Inflammation; Oxidative stress; Rat; Tartrazine; Thymoquinone
dc.titleThymoquinone played a protective role against tartrazine- induced
dc.typeArticle

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