Effect of high-intensity exercise on endoplasmic reticulum stress and proinflammatory cytokine levels

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dc.contributor.authorKorkmaz, K.
dc.contributor.authorDuzova, H.
dc.contributor.authorTaslidere, A. Cetin
dc.contributor.authorKoc, A.
dc.contributor.authorKaraca, Z. M.
dc.contributor.authorDurmus, K.
dc.date.accessioned2026-06-19T06:39:44Z
dc.date.available2026-06-19T06:39:44Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives. - High-intensity exercise impairs ER functions and elevates pro-inflammatory cytokines and neurotrophins levels. We investigated the effects of different intensity swimming exercises on ER stress of muscle damage with the impact of IL-23 and neurotrophic factors. Equipment and methods. - Rats were divided into three groups control (n = 9), normal swimming exercise (NSE) (n = 8), and weight-loaded swimming exercise (WLSE) (n = 9). Ventricle and skeletal muscle ATF4 and GRP78 levels were measured by Western Blot, and serum IL-17, IL-23, BDNF, NT-3, and NGF levels by ELISA method. Caspase-3 immunohistochemistry evaluation of skeletal muscle tissues was performed. Results. - The GRP78 level in the gastrocnemius muscle in the NSE group decreased, while the ATF4 level increased compared to other groups (P < 0.05). The ATF4 levels in heart muscle in the NSE group increased compared to the WLSE group (P < 0.05). The serum NT-3 level in the WLSE group rats increased compared to the other groups (P < 0.008). Intense Caspase-3 positive staining muscle cells were observed in the WLSE group compared to the control group (P <= 0.0001). Conclusions. - In response to high-intensity exercise, while pro-inflammatory cytokines, BDNF, and NGF adaptation in the body take place, also NT-3 secretion causing cell damage by the caspase system to cope with ER stress increasement is seen. In conclusion, this study shows us that high-intensity exercise may cause myopathy in the heart and skeletal muscle. (c) 2023 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipInonu University Scientific Research Foundation [2019-1747]
dc.description.sponsorshipThe authors wish to thank Gil Bisra Kaya, Faruk Disli, Zeynep Rumeysa Yoldas & nbsp;, and Mesut Celik from Inonu University Faculty of Medicine, Department of Physiology, who provided technical support in conducting the study. Inonu University Scientific Research Foundation supported this research under a grant (Project number: (TYT, 2019-1747) .
dc.identifier.doi10.1016/j.scispo.2022.04.009
dc.identifier.issn0765-1597
dc.identifier.issue4
dc.identifier.orcid0000-0001-8123-2150
dc.identifier.orcid0000-0002-1593-4960
dc.identifier.scopus2-s2.0-85148755649
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.scispo.2022.04.009
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5740
dc.identifier.volume38
dc.identifier.wosWOS:001016413300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofScience & Sports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectWeight-Loading Swimming Exercise
dc.subjectEr Stress
dc.subjectGrp78
dc.subjectAtf4
dc.subjectIl-17
dc.subjectIl-23
dc.subjectBdnf
dc.subjectNgf
dc.subjectNt-3
dc.subjectCaspase-3
dc.titleEffect of high-intensity exercise on endoplasmic reticulum stress and proinflammatory cytokine levels
dc.typeArticle

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