HIGHER LEVELS OF CIRCULATING CHEMERIN IN OBESE WOMEN WITH GESTATIONAL DIABETES MELLITUS

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dc.contributor.authorAdemoglu, E.
dc.contributor.authorBerberoglu, Z.
dc.contributor.authorDellal, F. D.
dc.contributor.authorAriel, M. Keskin
dc.contributor.authorKose, A.
dc.contributor.authorCandan, Z.
dc.contributor.authorBekdemir, H.
dc.date.accessioned2025-10-24T18:09:58Z
dc.date.available2025-10-24T18:09:58Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective. To characterize serum chemerin levels in obese patients with gestational diabetes mellitus (GDM). Design. Case control study. Subjects and Methods. Forty seven obese women with newly diagnosed GDM at 24-28 weeks of pregnancy and 32 age, body mass index- and gestational age-matched, normal pregnant women were included. Metabolic patterns and serum chemerin concentrations were measured. Results. Serum chemerin levels were significantly higher in subjects with GDM as compared to healthy pregnant controls (p < 0.05). Fasting insulin was similar between the two groups. HOMA-IR tended to be higher in GDM group but did not reach statistical significance. Women with GDM had significantly higher triglyceride (p < 0.01) and lower high-density lipoprotein cholesterol (p < 0.001) than controls. In multiple linear regression analyses, chemerin was significantly associated with BMI (beta-coefficient = 0.274, p = 0.01), HbA lc (beta-coefficient = 0.327, p < 0.01), HDL-cholesterol (beta-coefficient = -0.307, p < 0.01), triglyceride (beta-coefficient = 0.236, p < 0.05), insulin levels (beta-coefficient = 0.236, p < 0.05) and HOMA index (beta-coefficient = 0.283, p = 0.01). Conclusions. Maternal chemerin levels were significantly increased in GDM at 24-28 weeks of pregnancy. The physiological significance of elevated serum chemerin in GDM remains unclear.
dc.identifier.doi10.4183/aeb.2015.32
dc.identifier.endpage37
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue1
dc.identifier.startpage32
dc.identifier.urihttps://doi.org/10.4183/aeb.2015.32
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3906
dc.identifier.volume11
dc.identifier.wosWOS:000348634800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.ispartofActa Endocrinologica-Bucharest
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectchemerin; obesity; gestational diabetes mellitus
dc.titleHIGHER LEVELS OF CIRCULATING CHEMERIN IN OBESE WOMEN WITH GESTATIONAL DIABETES MELLITUS
dc.typeArticle

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