HIGHER LEVELS OF CIRCULATING CHEMERIN IN OBESE WOMEN WITH GESTATIONAL DIABETES MELLITUS
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Editura Acad Romane
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective. To characterize serum chemerin levels in obese patients with gestational diabetes mellitus (GDM). Design. Case control study. Subjects and Methods. Forty seven obese women with newly diagnosed GDM at 24-28 weeks of pregnancy and 32 age, body mass index- and gestational age-matched, normal pregnant women were included. Metabolic patterns and serum chemerin concentrations were measured. Results. Serum chemerin levels were significantly higher in subjects with GDM as compared to healthy pregnant controls (p < 0.05). Fasting insulin was similar between the two groups. HOMA-IR tended to be higher in GDM group but did not reach statistical significance. Women with GDM had significantly higher triglyceride (p < 0.01) and lower high-density lipoprotein cholesterol (p < 0.001) than controls. In multiple linear regression analyses, chemerin was significantly associated with BMI (beta-coefficient = 0.274, p = 0.01), HbA lc (beta-coefficient = 0.327, p < 0.01), HDL-cholesterol (beta-coefficient = -0.307, p < 0.01), triglyceride (beta-coefficient = 0.236, p < 0.05), insulin levels (beta-coefficient = 0.236, p < 0.05) and HOMA index (beta-coefficient = 0.283, p = 0.01). Conclusions. Maternal chemerin levels were significantly increased in GDM at 24-28 weeks of pregnancy. The physiological significance of elevated serum chemerin in GDM remains unclear.
Açıklama
Anahtar Kelimeler
chemerin; obesity; gestational diabetes mellitus
Kaynak
Acta Endocrinologica-Bucharest
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
11
Sayı
1
