Acute Disseminated Encephalomyelitis in Children and Adolescents: A Multicenter Retrospective Study of Relapse and Outcome

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dc.authoridOlgac Dundar, Nihal/0000-0002-5902-3501
dc.contributor.authorKanmaz, Seda
dc.contributor.authorYilmaz, Sanem
dc.contributor.authorDundar, Nihal Olgac
dc.contributor.authorAksoy, Ayse
dc.contributor.authorCanpolat, Mehmet
dc.contributor.authorPer, Huseyin
dc.contributor.authorErol, Ilknur
dc.date.accessioned2025-10-24T18:09:33Z
dc.date.available2025-10-24T18:09:33Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives To evaluate the demographic, clinical, laboratory, and prognostic data of children with acute disseminated encephalomyelitis with respect to anti-myelin oligodendrocyte glycoprotein (MOG) antibody status.Methods Acute disseminated encephalomyelitis patients (n = 245) from 24 centers followed up between 2010 and 2022 were evaluated retrospectively. The short- and long-term outcome characteristics (disease severity and course, clinical relapse, and recovery rates) were assessed. Incomplete clinical recovery was defined as modified Rankin Score >= 1 or the presence of epilepsy. Univariant and multivariant analysis were performed for outcome characteristics.Results The mean age at diagnosis was 6.3 +/- 3.8 (0.5-17.7) years and the median follow-up was 22 (3-132) months. The outcome characteristics were evaluated in 180 of 245 patients (73.4%) with at least 12 months' follow-up. Twenty-three patients (12.6%) relapsed. The multivariable logistic regression analysis revealed the following clinical parameters as predictors of relapse: sex, visual impairment, and ataxia at initial presentation. Incomplete clinical recovery (n = 42/180, 23.3%) was associated with the presence of seizures on admission and the need for an intensive care unit. Anti-MOG antibody positivity was not associated with an increased risk of relapse (25% vs 13.1%, P = .164) or incomplete clinical recovery (P = .511).Conclusion The nationwide cohort presented further supports the typically monophasic nature of acute disseminated encephalomyelitis, and a high rate of complete recovery. The presence of certain symptoms in the acute period may assist the clinician in estimating the outcome.
dc.identifier.doi10.1177/08830738251334219
dc.identifier.endpage851
dc.identifier.issn0883-0738
dc.identifier.issn1708-8283
dc.identifier.issue10
dc.identifier.pmid40340642
dc.identifier.startpage838
dc.identifier.urihttps://doi.org/10.1177/08830738251334219
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3683
dc.identifier.volume40
dc.identifier.wosWOS:001590983700006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofJournal Of Child Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectautoimmune; encephalitis; neuroimmunology; outcome
dc.titleAcute Disseminated Encephalomyelitis in Children and Adolescents: A Multicenter Retrospective Study of Relapse and Outcome
dc.typeArticle

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