Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

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dc.contributor.authorAKTAR, BEDRİYE SEDA KURSUN
dc.contributor.authorSICAK, Yusuf
dc.contributor.authororuç-emre, emine elçin
dc.date.accessioned2025-10-24T18:03:49Z
dc.date.available2025-10-24T18:03:49Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractA series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.
dc.identifier.doi10.32571/ijct.1003871
dc.identifier.endpage14
dc.identifier.issn2602-277X
dc.identifier.issue1
dc.identifier.startpage7
dc.identifier.trdizinid1104559
dc.identifier.urihttps://doi.org/10.32571/ijct.1003871
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1104559
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2472
dc.identifier.volume6
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofInternational Journal of Chemistry and Technology (IJCT)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectKimya
dc.subjectOrganik
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectChalcone
dc.subjectUrease inhibitory activity
dc.subjectAnticholinesterase activity
dc.subjectTyrosinase inhibitory activity
dc.titleSynthesis and biological activities of new hybrid chalcones with benzoic acid ring
dc.typeArticle

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