Protective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis

Basit Öğe Kaydı
dc.contributor.authorÖzyuvali, Ekrem
dc.contributor.authorYıldırım, Mehmet Erol
dc.contributor.authorYaman, Tunc Senem
dc.contributor.authorKösem, Bahadır
dc.contributor.authorAtli, O.
dc.contributor.authorÇimentepe, Ersin In
dc.date.accessioned2025-10-24T18:06:51Z
dc.date.available2025-10-24T18:06:51Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC). Material-Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP). Rats were randomly allocated to one of four groups (n = 6 per group): a control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1; a IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, a intravesical PRP-treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia. Results: Histological evaluation showed that bladder inflammation in CYP-treated rats was not suppressed by PRP. CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but PRP was not found to be effective to decrease these effects. Conclusion: The application of PRP could not reverse the histopathological changes in rats that had interstitial cystitis due to the cyclophosphamide injection. © 2017 Elsevier B.V., All rights reserved.
dc.identifier.endpageS120
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6
dc.identifier.pmid27917804
dc.identifier.scopus2-s2.0-85009951465
dc.identifier.scopusqualityQ2
dc.identifier.startpageS116
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3239
dc.identifier.volume39
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThe Canadian Society for Clinical Investigation csci@rcpsc.edu
dc.relation.ispartofClinical and Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subject[No keyword]
dc.titleProtective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu