Synthesis, Biological Activity Studies and Molecular Modeling Studies of Chalcone Compounds with Methyl Group

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dc.contributor.authorAKTAR, BEDRİYE SEDA KURSUN
dc.date.accessioned2025-10-24T18:03:49Z
dc.date.available2025-10-24T18:03:49Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractA series of new chalcone derivatives (1-5) were synthesized as a result of the Claisen-Schmidt condensation of different substituted methyl aldehydes of 4?-Piperazinoacetophenone. Anticholinesterase (AChE and BChE) inhibitory activity and antidiabetic (?-glucosidase and ?-amylase inhibitory) activities of the synthesized compounds were examined. While compound 1 is the most active molecule in AChE (IC50= 16.29±0.44 ?M), BChE (IC50 = 10.19±0.04 ?M) and ?-amylase (IC50= 105.51±0.24 ?M) inhibitor activities; Compound 5 was found to be the most active molecule in ?-glucosidase inhibitor activity. In silico and molecular docking studies of compounds 1-5 were performed. According to molecular docking results, all molecules were found to be more active than the reference compounds.
dc.identifier.doi10.32571/ijct.1389889
dc.identifier.endpage26
dc.identifier.issn2602-277X
dc.identifier.issue1
dc.identifier.startpage19
dc.identifier.trdizinid1243783
dc.identifier.urihttps://doi.org/10.32571/ijct.1389889
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1243783
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2474
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofInternational Journal of Chemistry and Technology (IJCT)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectMikroskopi
dc.subjectSpektroskopi
dc.subjectKimya
dc.subjectUygulamalı
dc.subjectKimya
dc.subjectTıbbi
dc.subjectToksikoloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.subjectFarmakoloji ve Eczacılık
dc.subjectMolecular docking
dc.subjectChalcone
dc.subjectanticholinesterase inhibitory
dc.subject?-amylase inhibitory
dc.subject?-glycosidase inhibitory
dc.titleSynthesis, Biological Activity Studies and Molecular Modeling Studies of Chalcone Compounds with Methyl Group
dc.typeArticle

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