Synthesis, Biological Activity Studies and Molecular Modeling Studies of Chalcone Compounds with Methyl Group
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
A series of new chalcone derivatives (1-5) were synthesized as a result of the Claisen-Schmidt condensation of different substituted methyl aldehydes of 4?-Piperazinoacetophenone. Anticholinesterase (AChE and BChE) inhibitory activity and antidiabetic (?-glucosidase and ?-amylase inhibitory) activities of the synthesized compounds were examined. While compound 1 is the most active molecule in AChE (IC50= 16.29±0.44 ?M), BChE (IC50 = 10.19±0.04 ?M) and ?-amylase (IC50= 105.51±0.24 ?M) inhibitor activities; Compound 5 was found to be the most active molecule in ?-glucosidase inhibitor activity. In silico and molecular docking studies of compounds 1-5 were performed. According to molecular docking results, all molecules were found to be more active than the reference compounds.
Açıklama
Anahtar Kelimeler
Mikroskopi, Spektroskopi, Kimya, Uygulamalı, Kimya, Tıbbi, Toksikoloji, Biyokimya ve Moleküler Biyoloji, Farmakoloji ve Eczacılık, Molecular docking, Chalcone, anticholinesterase inhibitory, ?-amylase inhibitory, ?-glycosidase inhibitory
Kaynak
International Journal of Chemistry and Technology (IJCT)
WoS Q Değeri
Scopus Q Değeri
Cilt
8
Sayı
1
