Efect of Ankaferd Blood Stopper on muscle healing

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dc.contributor.authorUygun, Murat
dc.contributor.authorYavuz, Osman Yüksel
dc.contributor.authorUraş, Ismail
dc.contributor.authorDuman, İbrahim Gökhan
dc.contributor.authorHaltaş, Hacer
dc.contributor.authorKömürcü, Mahmut
dc.date.accessioned2025-10-24T18:06:44Z
dc.date.available2025-10-24T18:06:44Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Ankaferd Blood Stopper (ABS), which is a standardized mixture of herbal extracts obtained from fve plants, has been proven as an efcient hemostatic agent and is still used in emergency situations. It is not known exactly if decreased bleeding has positive or negative efects on muscle healing and fbrosis, so the purpose of this study was to test the efect of ABS on muscle healing and morphology.Methods: A total of 66 outbred Wistar rats were divided into three control and three experimental subgroups. In the experimental groups, ABS was sprayed on the cut surface of the soleus. In the control groups, a saline solution was sprayed on the cut surface of the soleus. Subgroups were euthanized afer 2 weeks, 3 weeks and 4 weeks, respectively. In each subgroup, eight rats were used for the biomechanical study to determine muscle healing and three rats were used for the histopathological investigation.Results: Although muscle strength in the control groups was lower than that of the experimental groups in early weeks, no diferences were found between the control and the experimental groups at 4 weeks.Conclusions: ABS has no negative efect on muscle healing. We also observed that ABS accelerated muscle healing compared to the control group. ABS could be used in hemostasis of open fractures and elective orthopedic surgeries. © 2021 Elsevier B.V., All rights reserved.
dc.identifier.doi10.25011/CIM.V39I6.27526
dc.identifier.endpage191
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6
dc.identifier.pmid27917816
dc.identifier.scopus2-s2.0-85047584663
dc.identifier.scopusqualityQ2
dc.identifier.startpage187
dc.identifier.urihttps://doi.rog/10.25011/CIM.V39I6.27526
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3181
dc.identifier.volume39
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThe Canadian Society for Clinical Investigation
dc.relation.ispartofClinical and Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzScopus_20251023
dc.subjectankaferd blood stopper
dc.subjectplant extract
dc.subjectanimal
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectpathology
dc.subjectrat
dc.subjectskeletal muscle
dc.subjectWistar rat
dc.subjectwound healing
dc.subjectWounds, Penetrating
dc.subjectAnimals
dc.subjectMuscle, Skeletal
dc.subjectPlant Extracts
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectWound Healing
dc.titleEfect of Ankaferd Blood Stopper on muscle healing
dc.typeArticle

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