Neutrophil-lymphocyte ratio may be superior to C-reactive protein for predicting the occurrence of postmenopausal osteoporosis

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dc.contributor.authorYilmaz, Hakki
dc.contributor.authorUyfun, M.
dc.contributor.authorYılmaz, Tuğba S.
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorInan, Osman
dc.contributor.authorTaskin, A.
dc.contributor.authorÇakmak, Muzaffer
dc.date.accessioned2025-10-24T18:06:45Z
dc.date.available2025-10-24T18:06:45Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Recent studies revealed that inflammation plays a critical role in bone remodeling and the pathogenesis of postmenopausal osteoporosis, a major health concern. Neutrophil-lymphocyte ratio (NLR) is a cost-effective marker of inflammation that has been linked with several diseases. This study aimed to compare NLR and C-reactive protein (CRP) levels in osteopenic, osteoporotic, and control subjects and to assess the correlation between NLR levels, CRP, and bone mineral density (BMD) in postmenopausal women. Methods: In this cross-sectional study, the relationship between NLR, CRP, and BMD in 438 women was investigated using uni- and multivariate analyses. BMD (g/cm²) was measured by dual-energy X-ray absorptiometry (DEXA) at the lumbar spine and femur. Complete blood count (CBC), CRP, glucose/lipid metabolism, and established risk factors were determined. Results: In the osteoporotic group, NLR and CRP levels were found to be elevated as compared to the osteopenic and control groups (NLR: 4.68 ± 0.72, 3.17 ± 0.43, 2.01 ± 0.54; CRP: 12.3 ± 4.1, 4.1 ± 2.7, 3.2 ± 2.1, respectively). A negative correlation was present between NLR and the lumbar spine (L2-L4) and femoral neck BMD after adjusting other risk factors. There was no correlation between CRP levels and BMD after adjusting other risk factors. NLR was significantly associated with L2-L4 BMD (ß = -0.653, p<0.001) and femoral neck BMD (ß = -0.178, p<0.001), but CRP level had no association with BMD in a multivariate model. Conclusions: Our data indicate that NLR may be a better predictor than CRP for occurrence of osteoporosis in postmenopausal women. © 2015 Elsevier B.V., All rights reserved.
dc.identifier.doi10.4149/endo_2014_01_25
dc.identifier.endpage33
dc.identifier.issn1336-0329
dc.identifier.issn1210-0668
dc.identifier.issue1
dc.identifier.pmid24524373
dc.identifier.scopus2-s2.0-84903907778
dc.identifier.scopusqualityQ3
dc.identifier.startpage25
dc.identifier.urihttps://doi.rog/10.4149/endo_2014_01_25
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3188
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInstitute of Experimental Endocrinology ueenregu@kramare.savba.sk
dc.relation.ispartofEndocrine Regulations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectBMD
dc.subjectCRP
dc.subjectInflammation
dc.subjectMenopause
dc.subjectNLR
dc.subjectOsteoporosis
dc.titleNeutrophil-lymphocyte ratio may be superior to C-reactive protein for predicting the occurrence of postmenopausal osteoporosis
dc.typeArticle

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