Genome projects 5W1H: What, where, when, why, how and in which population?

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dc.contributor.authorFidanoğlu, Pelin
dc.contributor.authorBelder, Nevin
dc.contributor.authorDoğanay Erdoğan, Beyza
dc.contributor.authorIlk, Ozlem
dc.contributor.authorRajabli, Farid
dc.contributor.authorÖzdağ, Hil?al
dc.date.accessioned2025-10-24T18:06:51Z
dc.date.available2025-10-24T18:06:51Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractGenome projects aim to decode an organism's complete set of deoxyribonucleic acid (DNA), which can be described as the living code of organism. The idea of the Human Genome Project (HGP) was conceived in the early 1980s. The project was started at 1990 and finished at 2003. The sequencing of the whole human genome derived from the DNA of several anonymous volunteers, costed 3.8 billion dollars. In order to annotate the genome data, the "topography of the genome" and the anatomy of the genes should have been revealed. For this purpose, genome projects of several model organisms was carried out in parallel with HGP with the aim to identify basic structural components, organizational structure and evolutionarily development of the genome. With the advent of microarray technology in the early 2000s, high-throughput screening of Single Nucleotide Polymorphisms (SNPs) and Copy Number Variations (CNVs) became feasible. After the completion of HGP in 13 years, James D. Watson's genome was sequenced with 1 million dollar budget in just 2 months using next generation sequencing technology. Today a human genome can be sequenced in just one day with the cost of 6.600 USD. In this reviev the HGP which created big expectations especially in medicine will be explained from its start to the present. Then we will summarize the studies paving the road to personalized medicine emphasizing the fact that to reveal the meaning of genomic information, it should become computable. © 2014 Elsevier B.V., All rights reserved.
dc.identifier.doi10.5505/TurkHijyen.2014.14890
dc.identifier.endpage60
dc.identifier.issn0377-9777
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84900409362
dc.identifier.scopusqualityQ4
dc.identifier.startpage45
dc.identifier.urihttps://doi.rog/10.5505/TurkHijyen.2014.14890
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3220
dc.identifier.volume71
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherRefik Saydam National Public Health Agency (RSNPHA) turkhijyen@rshm.gov.tr
dc.relation.ispartofTurk Hijyen ve Deneysel Biyoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzScopus_20251023
dc.subjectHaplotype
dc.subjectHGP
dc.subjectSNP
dc.subjectVariation
dc.titleGenome projects 5W1H: What, where, when, why, how and in which population?
dc.title.alternativeGenom projeleri 5N1H: Ne, nerede, ne zaman, nasil, neden ve hangi popülasyonda?
dc.typeReview Article

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