Genome projects 5W1H: What, where, when, why, how and in which population?
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Refik Saydam National Public Health Agency (RSNPHA) turkhijyen@rshm.gov.tr
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Genome projects aim to decode an organism's complete set of deoxyribonucleic acid (DNA), which can be described as the living code of organism. The idea of the Human Genome Project (HGP) was conceived in the early 1980s. The project was started at 1990 and finished at 2003. The sequencing of the whole human genome derived from the DNA of several anonymous volunteers, costed 3.8 billion dollars. In order to annotate the genome data, the "topography of the genome" and the anatomy of the genes should have been revealed. For this purpose, genome projects of several model organisms was carried out in parallel with HGP with the aim to identify basic structural components, organizational structure and evolutionarily development of the genome. With the advent of microarray technology in the early 2000s, high-throughput screening of Single Nucleotide Polymorphisms (SNPs) and Copy Number Variations (CNVs) became feasible. After the completion of HGP in 13 years, James D. Watson's genome was sequenced with 1 million dollar budget in just 2 months using next generation sequencing technology. Today a human genome can be sequenced in just one day with the cost of 6.600 USD. In this reviev the HGP which created big expectations especially in medicine will be explained from its start to the present. Then we will summarize the studies paving the road to personalized medicine emphasizing the fact that to reveal the meaning of genomic information, it should become computable. © 2014 Elsevier B.V., All rights reserved.
Açıklama
Anahtar Kelimeler
Haplotype, HGP, SNP, Variation
Kaynak
Turk Hijyen ve Deneysel Biyoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
71
Sayı
1
